Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines
Nature Communications June 3, 2019 Farhan Ali, Danielle M. Gerhard, Katherine Sweasy et al. 201 citations
A subanesthetic dose of ketamine causes acute psychotomimetic symptoms and sustained antidepressant effects. In prefrontal cortex, the prevailing disinhibition hypothesis posits that N-methyl-d-aspartate receptor (NMDAR) antagonists such as ketamine act preferentially on GABAergic neurons. However, cortical interneurons are heterogeneous. In particular, somatostatin-expressing (SST)...