Cannabis use induces a plethora of actions on the CNS via its active chemical ingredients, the so-called phytocannabinoids. These compounds have been frequently associated with the intoxicating properties of cannabis preparations. However, not all phytocannabinoids are psychotropic, and, irrespective of whether they are psychotropic or not, they have also shown numerous therapeutic properties....
Abstract What is the relationship between consciousness and semiosis? This article attempts to provide some clues to answer this question. For doing it, we explore the application of the Integral model to semiotics; that is to say, the metatheory that integrates the inside, the outside, the individual, and the collective dimension, on one hand and, on the other hand, the levels of development,...
Background: Synthetic cathinone derivatives are used as alternatives both for stimulant drugs such as cocaine and methamphetamine and for club drugs such as 3,4-methylenedioxymethamphetamine (MDMA), but little is known about their MDMA-like subjective effects. Methods In order to determine their similarity to MDMA, the discriminative stimulus effects of 10 pyrrolidinyl cathinones...
July 1, 2020Nathaniel A. Shanok, Carol Reive, Krystal D. Mize et al.
Abstract. Mindfulness meditation interventions (MMIs) are formal training programs which utilize mindfulness techniques to improve attentional control and reduce stress and anxiety. Past investigat...
Forensic Science InternationalJuly 1, 2020Ana Flávia Belchior de Andrade, Mathieu Elie, Christian Weck et al.8 citations
The continuous emergence of NPS over the last years poses a series of novel challenges for forensic analysts. Most of those new compounds are synthesized with minimal chemical modifications to the structure of already known chemicals in order to avoid regulations. Some of these new compounds may undergo chemical changes during analysis leading to misidentification and detrimental legal...
Abstract Since 2006, there has been a resurgent interest in the pharmacology and therapeutics of psychedelic drugs. Psilocybin, the 4‐phosphoryl ester of N,N ‐dimethyltryptamine (DMT), has been studied most often, but DMT itself is also appealing because of its brief but profound psychological effects and its presence as an endogenous substance in mammalian brain. Although there have been a few...
Consciousness is, probably, the most common and the most mysterious experience in human life. It encompasses a stream of mental activities that include knowledge and recognition, emotions and feelings, organic dispositions, and linguistic acts, as well as altered states such as those provoked by drugs and pathologies, and mystical moments. The philosophy of mind is habitually reprimanded for...
Approximately one-third of patients presenting with a first episode of psychosis have a history of cannabis use. Some of these patients meet the criteria for cannabis-induced psychotic disorder (CIPD), which is regarded as a disorder with better outcomes compared to other psychotic disorders. The aim of this paper was to determine whether there are differences in clinical and demographic...
Ketamine, a dissociative anesthetic, is experiencing a clinical resurgence as a fast-acting antidepressant. In the central nervous system, ketamine acts primarily by blocking NMDA receptor currents. Although it is generally safe in a clinical setting, it can be addictive, and several of its derivatives are being investigated as preferable alternatives. 2R,6R-Hydroxynorketamine (HNK), a ketamine...
Gregory of Nyssa and Dionysius the Areopagite both contemplate the Exodus narrative of Moses’ experiences on Sinai. That narrative is complex, with Moses ascending and descending the mountain several times, sometimes in company, sometimes alone. Gregory follows the biblical twists and turns in Life of Moses; the relevant paragraph in Dionysius’ Mystical Theology tells of just one ascent. This...