Drug Testing and Analysis
December 1, 2024
Keeper Trout, Paul F. Daley
5 citations
The story of the 1967 appearance of the powerful psychedelic 2,5-dimethoxy-4-methylamphetamine (DOM, STP) commonly omits details and often includes hyperbole and inaccuracies. It is well known how and when the drug was first distributed to the public for free by Owsley Stanley, but the role that Alexander Shulgin played in providing that material is not as well understood. In the interest of...
Zenodo (CERN European Organization for Nuclear Research)
2023
Paul F. Daley
Paul Daley - Alexander Shulgin Research Institute (psychedelic molecules, 4th-5th September 2023, Prague, Czech Republic)
Drug Testing and Analysis
July 1, 2020
Nicholas V. Cozzi, Paul F. Daley
12 citations
Abstract Since 2006, there has been a resurgent interest in the pharmacology and therapeutics of psychedelic drugs. Psilocybin, the 4‐phosphoryl ester of N,N ‐dimethyltryptamine (DMT), has been studied most often, but DMT itself is also appealing because of its brief but profound psychological effects and its presence as an endogenous substance in mammalian brain. Although there have been a few...
Neuropharmacology
November 1, 2018
Landon M. Klein, Nicholas V. Cozzi, Paul F. Daley et al.
43 citations
Substantial effort has been devoted toward understanding the psychopharmacological effects of tryptamine hallucinogens, which are thought to be mediated by activation of 5-HT2A and 5-HT1A receptors. Recently, several psychoactive tryptamines based on the N,N-diallyltryptamine (DALT) scaffold have been encountered as recreational drugs. Despite the apparent widespread use of DALT derivatives in...
Bioorganic & Medicinal Chemistry Letters
February 1, 2016
Nicholas V. Cozzi, Paul F. Daley
24 citations
N,N-Diallyltryptamine (DALT) and 5-methoxy-N,N-diallyltryptamine (5-MeO-DALT) are two tryptamines synthesized and tested by Alexander Shulgin. In self-experiments, 5-MeO-DALT was reported to be psychoactive in the 12-20mg range, while the unsubstituted compound DALT had few discernible effects in the 42-80 mg range. Recently, 5-MeO-DALT has been used in nonmedical settings for its psychoactive...
Drug Testing and Analysis
2012
Simon D. Brandt, Ruchanok Tearavarich, Nicola M. Dempster et al.
10 citations
The absence of reference material is a commonly experienced difficulty among medical and forensic professionals tasked with identifying new psychoactive substances that are encountered for the first time. The identification of newly emerging substances lies at the heart of forensic and clinical analysis, and a proactive public health policy calls for a thorough analysis of the properties of new...
Drug Testing and Analysis
December 29, 2010
Ruchanok Tearavarich, Viwat Hahnvajanawong, Nicola M. Dempster et al.
10 citations
The increased interest in N,N-dialkyl tryptamines is a reflection of their diverse range of biologically active properties. Deuterated derivatives are of interest for use as internal standards in bioanalytical or pharmacological assays. The present study reports on the synthesis of twelve novel 5-ethoxy-N,N-dialkyl-[α,α,β,β-H(4) ]-tryptamines and their [α,α,β,β-D(4) ]-counterparts following the...
Journal of Ethnopharmacology
July 15, 2010
Olabode Ogunbodede, Douglas Mccombs, Keeper Trout et al.
54 citations
Aim of the studyThe aim of the present study is to determine in a procedurally uniform manner the mescaline concentrations in stem tissue of 14 taxa/cultivars of the subgenus Trichocereus of the genus Echinopsis (Cactaceae) and to evaluate the relationship (if any) between mescaline concentration and actual shamanic use of these plants.Materials and methodsColumnar cacti of the genus...
J Neural Transm (Vienna)
September 12, 2009
Nicholas V. Cozzi, Anupama Gopalakrishnan, Lyndsey L. Anderson et al.
144 citations
N,N-dimethyltryptamine (DMT) is a potent plant hallucinogen that has also been found in human tissues. When ingested, DMT and related N,N-dialkyltryptamines produce an intense hallucinogenic state. Behavioral effects are mediated through various neurochemical mechanisms including activity at sigma-1 and serotonin receptors, modification of monoamine uptake and release, and competition for...