CureusMarch 30, 2022Carolina Sepulveda Ramos, Matthew P. Thornburg, Kelly A Long et al.9 citations
Ketamine, a non-competitive N-methyl-d-aspartate receptor antagonist, is commonly used as an anesthetic and analgesic but has recently shown promising research in treating certain psychiatric conditions such as depression, post-traumatic stress disorder (PTSD), suicidal ideation, and substance use disorder. Due to its euphoric, dissociative, and hallucinogenic properties, ketamine has been...
Seorang anak bisa menjadi anak jalanan tentu mempunyai hal yang melatarbelakangi dalam kehidupannya. Sehingga anak jalanan sangat rentan untuk terjerumus kedalam perilaku menyimpang salah satunya adalah perilaku inhalasi zat adiktif seperti Lysergic Acid Diethylamide (LSD). Tujuan penelitian ini untuk mengeksplorasi dan menggambarkan pengalaman anak jalanan usia remaja dalam perilaku inhalasi...
The author describes the importance of numinous experience for Jung, and presents a range of ways in which such experiences might appear. The examples include numinous dreams, visions, experiences in the natural world, through the body, and by means of entheogens. The paper makes the point that whether these experiences are taken at face value or interpreted reductively depends on the...
The predictive coding theory of psychosis posits that individuals with schizophrenia demonstrate abnormalities in the strength of top-down modulation (based on prior experience) of sensory signals. Evidence suggests that difficulty perceiving depth inversion illusions (DIIs) (i.e., more accurate perception of stimuli under conditions in which control subjects perceive these illusions) may...
Clinical Case StudiesMarch 25, 2022H. Seesink, Pieter Klokkenburg, H. Schaap-Jonker et al.4 citations
This case study focuses on the treatment of a 44-year-old Dutch man presenting with an anxious God representation and religious struggles according to DSM-5 criteria. Having received prior treatment for a panic disorder and alcohol use disorder, the patient was given a 60-day treatment in which the Jesus Prayer intervention was used to address his religious and spiritual problems. To our...
Recently, there has been an increase in studies yielding evidence for psychedelics' anxiolytic and anti-depressive qualities. Preliminary evidence for treatment in substance addiction is also available. In our manuscript, we present a perspective on the possible effectiveness and mechanisms of action of psychedelics' introduction in the treatment of Compulsive Sexual Behavior Disorder (CSBD)...
Abstract Rationale LSD is the prototypical psychedelic. Despite a clear central role of the 5HT 2a receptor in its mechanism of action, the contributions of additional receptors for which it shows affinity and agonist activity remain unclear. Objectives We employed receptor-enriched analysis of functional connectivity by targets (REACT) to explore differences in functional connectivity (FC)...
This commentary suggests that the physical substrate of integrated information is dependent on the reference frame used to observe it. Furthermore, it uses a thought experiment - can a neuroscientist, locked in a closed room and connected through Zoom with his grandmother to demonstrate that the consciousness of his grannie is NOT in the PC? - to underline the problems that neglecting reference...
Integrated information theory postulates that a conscious experience depends on a repertoire of hypothetical experiences (the axiom of information). This makes consciousness depend on the context that constrains the set of possibilities and on the scenarios imagined by the external observer, and not only on the system itself.
In India the philosophers, except the Madhyamika Buddhists and Jayarasi Bhatta, maintain that determination of an object depends on a pramana, a source of cognition. Similarly, pramana depends on prameya padhartha. In the present paper I will deal with the relationship between epistemology and metaphysics from the Advaita point of view. According to Advaita Vedanta, Brahman is the only highest...