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C&EN Global Enterprise March 7, 2022 Bethany Halford
Over the past decade, psychedelic compounds like psilocybin and ecstasy have emerged as potentially life-changing treatments for mental illnesses, including major depressive disorder and posttraumatic stress disorder. Read on to learn how some companies are trying to bring these once-demonized drugs to market and how others are hoping to use chemistry to eliminate their hallucinogenic effects—a...
Frontiers in Psychology March 4, 2022 Agnieszka D. Sekula, Luke A. Downey, Prashanth Puspanathan 27 citations
Psychotherapy with the use of psychedelic substances, including psilocybin, lysergic acid diethylamide (LSD), ketamine, and 3,4-methylenedioxymethamphetamine (MDMA), has demonstrated promise in treatment of post-traumatic stress disorder (PTSD), anxiety, addiction, and treatment-resistant depression. Psychedelic-assisted psychotherapy (PP) represents a unique psychopharmacological model that...
BENTHAM SCIENCE PUBLISHERS eBooks March 3, 2022 Raul Franco Valverde
The three major schools of thought on the origin of consciousness are neuroscientists, sceptics, and quantum physicists. The quantum school explains consciousness using quantum theories, claiming that consciousness has a quantum origin, is non-local, and is created from vibrating entities that can have multiple versions depending on the observer's perception. Although most traditional...
Frontiers in Behavioral Neuroscience March 2, 2022 Yaping Chen, Mengxin Shen, Xu Liu et al.
Accumulating evidence suggests that glutamate clearance plays a critical role in the pathophysiology and treatment of depression. Preclinical and clinical studies have demonstrated that ketamine provides an immediate and sustained antidepressant effect. However, the precise mechanism of its action remains to be elucidated. Glutamate transporter 1 (GLT1) participates in glutamate clearance;...
Progress in Neurobiology March 2022 Sima Mofakham, Yuhao Liu, Asher Hensley et al.
Major theories of consciousness predict that complex electroencephalographic (EEG) activity is required for consciousness, yet it is not clear how such activity arises in the corticothalamic system. The thalamus is well-known to control cortical excitability via interlaminar projections, but whether thalamic input is needed for complexity is not known. We hypothesized that the thalamus...
Applied Psychophysiology and Biofeedback March 2022 Emma M. Millon, Paul M Lehrer, Tracey J. Shors
Mental and physical (MAP) training targets the brain and the body through a combination of focused-attention meditation and aerobic exercise. The following feasibility pilot study tested whether 6 weeks of MAP training improves mental health outcomes, while enhancing discrimination learning and heart rate variability (HRV) in a group of women living with human immunodeficiency virus (HIV) and...
Journal of Psychopharmacology March 1, 2022 Catherine Bird, A. H. Young
As we head into the (Northern Hemisphere) spring, the Journal publishes another set of papers which illustrate the robust health of the science of psychopharmacology. Once again, papers mostly focus on psychedelic drugs and related topics reflecting the zeitgeist (Young, 2022). de Wit et al. (2022) explore translational challenges and opportunities between clinical research and laboratory...
Molecular and cellular neurosciences March 1, 2022 Muhammad Asim, B. Hao, Abdul Waris et al.
Post-traumatic stress disorder (PTSD) is a devastating mental illness with high morbidity and major social and economic burden. Currently, there is no promising therapy available for the treatment of PTSD. Some clinical studies showed that ketamine could effectively alleviate PTSD symptoms. However, it is still unclear which brain region ketamine targets and how it attenuates the PTSD-like...
The Journal of Nervous and Mental Disease March 1, 2022 Kyle Possemato, Nina Silander, Nardos Bellete et al.
ABSTRACT: Although nightmares are known to predict the clinical course of posttraumatic stress disorder (PTSD), research on the relationship between specific nightmare characteristics and PTSD severity is sparse. This study conducted a secondary analysis to explore how five nightmare characteristics are cross-sectionally related to PTSD severity in 76 combat veterans with PTSD and at-risk...
International Journal of Nursing Science March 1, 2022 Hossam Alhawatmeh, Sami M. Alshammari, Jehad A. Rababah
Objective This study aimed to examine the effects of mindfulness meditation on trait mindfulness, perceived stress, emotion regulation, and quality of life in end-stage renal disease patients undergoing hemodialysis. Methods An experimental study with repeated measures design was conducted among a sample of 74 end-stage renal disease patients undergoing hemodialysis between January and May 2021...