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Mei Huang

3 papers in the library · publishing 2011-2022

Papers

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Repeated administration of rapastinel produces exceptionally prolonged rescue of memory deficits in phencyclidine-treated mice.

Behavioural Brain Research August 26, 2022 Lakshmi Rajagopal, Mei Huang, Wenqi He et al.

Rapastinel, a positive N-methyl-D-aspartate receptor (NMDAR) modulator with rapid-acting antidepressant properties, rescues memory deficits in rodents. We have previously reported that a single intravenous dose of rapastinel, significantly, but only transiently, prevented and rescued deficits in the novel object recognition (NOR) test, a measure of episodic memory, produced by acute or...

DOI: 10.1016/j.bbr.2022.113964 (opens in new tab) Full text (opens in new tab) Ketamine Antidepressant Novel object recognition Operant reversal learning +2

TPA-023 attenuates subchronic phencyclidine-induced declarative and reversal learning deficits via GABAA receptor agonist mechanism: possible therapeutic target for cognitive deficit in schizophrenia.

Neuropsychopharmacology November 2018 Lakshmi Rajagopal, Mei Huang, Eric Michael et al.

GABAergic drugs are of interest for the treatment of anxiety, depression, bipolar disorder, pain, cognitive impairment associated with schizophrenia (CIAS), and other neuropsychiatric disorders. Some evidence suggests that TPA-023, (7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b] pyridazine), a GABAA α2,3 subtype-selective GABAA partial...

DOI: 10.1038/s41386-018-0160-3 (opens in new tab) Full text (opens in new tab)

Interaction of mGlu2/3 agonism with clozapine and lurasidone to restore novel object recognition in subchronic phencyclidine-treated rats.

Psychopharmacology September 2011 Masakuni Horiguchi, Mei Huang, Herbert Y. Meltzer

Subchronic administration to rodents of the N-methyl-D-aspartate non-competitive antagonist, phencyclidine (PCP), impairs novel object recognition (NOR). Atypical antipsychotic drugs (APDs) reverse the effects of subchronic PCP on NOR. The effect of metabotropic glutamate₂/₃ receptor (mGlu₂/₃) agonists upon NOR is unknown. We tested the hypotheses that the mGlu₂/₃ agonist, LY379268, by itself,...

DOI: 10.1007/s00213-011-2251-2 (opens in new tab) Full text (opens in new tab)