3,4-Methylenedioxymethamphetamine (MDMA), a synthetic psychoactive amphetamine derivative widely abused as the recreational drug “ecstasy,” is associated with oxidative stress–mediated cardiotoxicity and hematological disturbances. Despite documented antioxidant properties of quercetin and vitamin E individually, limited evidence exists regarding their combined protective efficacy against...
It is common to distinguish between "holist" and "reductionist" views of brain function, where the former envisions the brain as functioning as an indivisible unit and the latter as a collection of distinct units that serve different functions. Opposing reductionism, a number of researchers have pointed out that cortical network architecture does not respect functional boundaries, and the...
We previously reported that co-expression of the Gi-coupled metabotropic glutamate receptor 2 (mGlu2R) and the Gq-coupled serotonin (5-HT) 2A receptor (2AR) in Xenopus oocytes (Fribourg et al. Cell 147:1011–1023, 2011) results in inverse cross-signaling, where for either receptor, strong agonists suppress and inverse agonists potentiate the signaling of the partner receptor. Importantly,...