Clarifying the mechanisms of loss and recovery of consciousness in the brain is a major challenge in neuroscience, and research on the spatiotemporal organization of rhythms at the brain region scale at different levels of consciousness remains scarce. By applying computational neuroscience, an extended corticothalamic network model was developed in this study to simulate the altered states of...
Contemplative scholarship has recently reoriented attention towards the neuroscientific study of the soteriological ambition of Buddhist practice, 'awakening'. This article evaluates the project of seeking neural correlates for awakening. Key definitional and operational issues are identified demonstrating that: the nature of awakening is highly contested both within and across Buddhist...
Nurses experience various health-related issues due to the nature of their work. This study aimed to examine the effect of a mindfulness-based intervention on stress overload, depression and mindfulness among nurses. A secondary objective was to examine the role of the setting (i.e., in and out of the hospital as a natural setting) on mindfulness-based intervention effectiveness. A randomized...
Traumatic brain injury (TBI) is a leading cause of disability. Sequelae can include functional impairments and psychiatric syndromes such as post-traumatic stress disorder (PTSD), depression and anxiety. Special Operations Forces (SOF) veterans (SOVs) may be at an elevated risk for these complications, leading some to seek underexplored treatment alternatives such as the oneirogen ibogaine, a...
Differences in the pharmacological effects of (S)-ketamine and (R)-ketamine are at the focus of research. Clinical data and our rat studies confirmed the antidepressant effect of (S)- but not (R)-ketamine, with similar differences in quantitative electroencephalogram (EEG) and sleep effects. In contrast, studies mainly on mice showed some stronger, preferable effects of (R)-ketamine. EEG theta...
Psychedelic drugs, which share in common 5-HT2A receptor agonist activity, have shown promise in treating alcohol-use disorders (AUDs). Repeated exposure to ethanol (EtOH) induces molecular and behavioural changes reflective of neuroadaptations that may contribute to addiction. Psychedelic drugs can induce neuroplasticity also, raising the possibility that their potential clinical effects in...
Psychedelics have traditionally been used for spiritual and recreational purposes, but recent developments in psychotherapy have highlighted their potential as therapeutic agents. These compounds, which act as potent 5-hydroxytryptamine (5HT) agonists, have been recognized for their ability to enhance neural plasticity through the activation of the serotoninergic and glutamatergic systems....
Abstract: The purpose of the present study the 30 male students were selected randomly as subjects from the B.P.Ed. class of Government College of Physical Education, Bhubaneswar, Odisha within the age group of 21 to 30 years of age. Anxiety was selected as the dependent variable for the study. Total subjects were divided into three groups (two experimental groups and one control group) equally...
The interrogation of the sacred proposed by Rudolf Otto’s metaphysical theology is not so much an answerless question as it is a conceptual open invitation to becoming aware of the phenomenon of meeting sacrality. It is also desired to become aware of the limits of reason in the process of analyzing the phenomenology of the sacred. Thus, the irrational is assumed to have the sense of mystery...
Photopharmacology is a vivid field of research that combines the unsurpassed spatiotemporal resolution of light with the principles of pharmacology. By introduction of synthetic chemical photoswitches into the structures of biologically active compounds, researchers can obtain control over biological processes. This is especially useful in the research of G protein-coupled receptors (GPCRs)...