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Jackob N. Keynan

3 papers in the library · 66 citations · publishing 2024-2026

Papers

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Increased cortical thickness and decreased brain age among special operations veterans with blast TBI after a magnesium-ibogaine protocol

iScience February 21, 2026 Andrew Geoly, John P. Coetzee, Derrick Matthew Buchanan et al.

= 22). Longitudinal analyses assessed cortical thickness, subcortical volume, and predicted brain age (pBA), estimated from T1 scans. pBA was significantly reduced at 1 month relative to baseline (-1.3 years). Cortical thickness analysis revealed post-treatment increases in 11 regions. Subcortical analyses revealed significant volumetric expansion in 8 regions. Magnesium-ibogaine therapy was...

DOI: 10.1016/j.isci.2026.115121 (opens in new tab) Protocol science Traumatic brain injury Brain aging Neurology +2

Neural correlates of ibogaine: Evidence from functional neuroimaging of military veterans

Biological Psychiatry Cognitive Neuroscience and Neuroimaging February 1, 2026 Malvika Sridhar, Azeezat Azeez, Andrew Geoly et al.

BackgroundIbogaine was recently found to result in significant functional improvements in treating the sequelae of traumatic brain injury (TBI) among Special Operations Forces veterans (SOVs). In the current study, we used multimodal neuroimaging to elucidate the neural correlates of ibogaine in 30 male SOVs who received ibogaine treatment.MethodsArterial spin labeling and blood oxygen...

DOI: 10.1016/j.bpsc.2026.02.001 (opens in new tab) Functional neuroimaging Neural activity Functional brain imaging Functional connectivity +2

Magnesium-ibogaine therapy in veterans with traumatic brain injuries.

Nature Medicine February 1, 2024 Kirsten Cherian, Jackob N. Keynan, Lauren Anker et al. 66 citations

Traumatic brain injury (TBI) is a leading cause of disability. Sequelae can include functional impairments and psychiatric syndromes such as post-traumatic stress disorder (PTSD), depression and anxiety. Special Operations Forces (SOF) veterans (SOVs) may be at an elevated risk for these complications, leading some to seek underexplored treatment alternatives such as the oneirogen ibogaine, a...

DOI: 10.1038/s41591-023-02705-w (opens in new tab) Full text (opens in new tab) Tbi treatment Brain injury recovery Tbi intervention Head injury treatment +17