The study of mysticism has been at an impasse for many years, wavering between naïve realism around a common core hypothesis and critical questioning of the category of mysticism and its imposition. In this article, we review key 20th century developments in the study of mysticism to understand why the term was largely abandoned and unpack the contours of this impasse. Specifically, we probe...
Cell ReportsDecember 24, 2024Lim-Anna Sieu, Shobhit Singla, Jiayang Liu et al.8 citations
Patients with focal temporal lobe seizures often experience loss of consciousness associated with cortical slow waves, like those in deep sleep. Previous work in rat models suggests that decreased subcortical arousal causes depressed cortical function during focal seizures. However, these studies were performed under light anesthesia, making it impossible to correlate conscious behavior with...
There is renewed interest in psychedelics, such as psilocybin, as therapies for multiple difficult-to-treat psychiatric disorders. Even though psychedelics can induce highly pleasant or aversive experiences, depending on multiple personal and environmental factors, there is little research into how such experiences impact post-acute mood-altering actions. Here we aimed at offsetting this gap....
Abstract Adolescent depression is a significant public health concern, yet treatment options remain limited, particularly due to age- and sex-related differences in antidepressant efficacy. This study explored the rapid and long-lasting antidepressant-like potential of psilocybin in adolescent Sprague-Dawley rats, examining acute and repeated oral dosing effects while incorporating sex as a...
ALSUntangled reviews alternate and off-label treatments prompted by patient interest. Here, we review psilocybin, a chemical derived from mushrooms and belonging in the category of drugs known as psychedelics. Psilocybin has plausible mechanisms for slowing ALS progression because of its ability to cross the blood brain barrier and effect neurogenesis and inflammation. Currently, there are no...
N,N-Dimethyltryptamine (DMT) is a fast-acting psychedelic drug that induces a radical reorganisation of conscious contents and brain dynamics. However, our understanding of how brain dynamics support psychedelic-induced conscious states remains unclear. We therefore present a repeated-measures dose-dependent study of the subjective and neural dynamics induced through DMT under naturalistic...
The moral status of human brain organoids (HBOs) has been debated in view of the future possibility that they may acquire phenomenal consciousness. This study empirically investigates the moral sensitivity in people's intuitive judgments about actions toward conscious HBOs. The results showed that the presence/absence of pain experience in HBOs affected the judgment about the moral...
According to the QBIT theory, consciousness depends on the emergence of macroscopic coherence in a specific intracellular substrate which registers and processes sensory information. This occurs in a particular neuronal compartment called the axon initial segment which has unique properties not found in other neuronal segments. These unique properties allow the integration of synaptic inputs,...
Abstract N,N -dimethyltryptamine (DMT) is a serotonergic psychedelic that is known for its short-lasting effects when administered intravenously. Several studies have investigated the administration of intravenous boluses or combinations of a bolus and a subsequent continuous infusion. However, data on dose-dependent acute effects and pharmacokinetics of continuous DMT infusions are lacking. We...
Dr. Alaina M. Jaster is a postdoctoral scholar in the Department of Psychiatry and Behavioral Neurosciences at Wayne State University. She currently serves on the trainee editorial board of Psychedelic Medicine, the journal for the International Society for Research on Psychedelics (ISRP), and is part of the Society's Diversity Equity Inclusion and Accessibility committee. Jaster is also part...