Health and SocietyJanuary 8, 2025Eduardo D’avila Lins Lacerda, Bianca Medeiros Ferraz da Nóbrega, Yasmin Mesquita Dias Franca Gadelha et al.
Psychedelics have emerged as a promising approach to treating mental disorders, challenging traditional paradigms in psychiatry. This study conducted an integrative literature review to investigate the advances, challenges, and implications of the therapeutic use of these substances, addressing the guiding question: “What are the current scientific perspectives on the use of psychedelics in the...
There are currently no evidence-based treatment guidelines for antisocial personality disorder (ASPD). Instead, treatment typically focuses on comorbid conditions. There is currently no literature documenting cases or research, theoretical or otherwise of using ketamine-assisted therapy or any other psychedelic therapy in cases of ASPD. In this case report, a 43-year-old man seeking...
Chronic pain affects approximately 1.5 billion people worldwide, representing the leading cause of disability and a significant financial burden on healthcare systems. Conventional treatments, such as opioids and non-steroidal anti-inflammatory drugs, are frequently linked to adverse effects, including dependency and gastrointestinal issues, and often offer limited long-term relief. This review...
Ketamine is an NMDA receptor antagonist that has antidepressant and anesthetic properties. At subanesthetic doses, ketamine induces transient psychosis in humans, and is used to model psychosis in experimental animals. In rodents, subanesthetic doses of ketamine increase the power of high-frequency oscillations (HFO, > 100 Hz) in the electroencephalogram (EEG), a frequency band linked to...
ABSTRACT There is growing interest to investigate classic psychedelics as potential therapeutics for mental illnesses. Previous studies have demonstrated that one dose of psilocybin leads to persisting neural and behavioral changes. The durability of psilocybin’s effects suggests that there are likely alterations of gene expression at the transcriptional level. In this study, we performed...
ObjectiveThough there is a rich psychoanalytic tradition investigating the content and phenomenology of dreams, the clinical use of this has fallen into widespread disuse. We have undertaken a narrative review of the clinical significance and utility of dream content.FindingsDream content may have useful clinical and prognostic value in a number of neurological and psychiatric conditions,...
Resting‐state functional connectivity analyses have been used to examine synchrony in neural networks in substance use disorders (SUDs), with the default mode network (DMN) one of the most studied. Prior research has generally found less DMN synchrony during use and greater synchrony during cessation, although little research has utilized this method with opioid use. This study examined resting...
This study aimed to investigate the effectiveness of mindfulness-based cognitive therapy (MBCT) on positive and negative emotions, sleep quality, and rumination among women with irritable bowel syndrome (IBS). This applied quasi-experimental research used a pretest-posttest design with a control group. The statistical population included all women diagnosed with IBS who referred to hospitals...
Key Points Question During buprenorphine treatment, does group-based mindfulness training reduce opioid use, craving, and anxiety compared with group recovery support? Findings In this randomized clinical trial including 196 adults prescribed buprenorphine for opioid use disorder, mindfulness was not superior at reducing illicit opioid use compared with an active group intervention with an...
In this paper I will argue that self-awareness and world-awareness are inherently embodied, with the embodied first-person perspective as their primary structure. Challenging dominant views, I contend that the first-person perspective is not reducible to subjective ownership of experiences or linguistic self-reference but arises from the body’s role as the zero-point of an oriented spatial...