Psilocybin is a hallucinogen with complex neurobiological and behavioral effects. This is the first study to use MRI to follow functional changes in brain activity in response to different doses of psilocybin in fully awake, drug naive rats. We hypothesized that psilocybin would show a dose-dependent increase in activity in the prefrontal cortex and thalamus, while decreasing hippocampal...
Neurobiology of StressMay 1, 2025Alanna Kit, Kate Conway, Savannah Makarowski et al.5 citations
There is growing interest in exploring the therapeutic potential and mechanisms of action of psilocybin on stress-related neuropsychiatric disorders, including depression, generalized anxiety disorder (GAD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), addiction, and disordered eating. Despite promising progressions in preclinical and clinical research, the...
The purpose of the study was to describe the benefits and harm of using psychedelics in the treatment of patients with mental health and substance abuse disorders. The study focused on classic psychedelics, specifically psilocybin and LSD. The study was carried out as an integrative literature review and the data was sought using Medic, Cinahl, PubMed MEDLINE and PsycINFO databases. A total of...
Ketamine is currently gaining attention as a rapid-acting antidepressant for treatment-resistant depression (TRD). However, many patients fail to respond, and limited data exist on predictors of non-response. This study aims to characterize the sociodemographic and clinical features associated with non-response to ketamine among TRD patients. This is a post-hoc analysis of a naturalistic...
Psychedelika jsou psychoaktivn ltky, kter bezprostedn po uit typicky vyvolvaj zmny vnmn, mylen, emotivity a kognitivnch proces. V posledn dob se intenzivn zkoum jejich antidepresivn a anxiolytick efekt. Hlavn vhodou tchto ltek je rychl nstup inku s dlouhodobm inkem po podn jedn i jen nkolika mlo dvek. Maj tak dobr bezpenostn profil. Dal vyuit mohou mt tyto ltky v lb chronickch bolest u...
This chapter explores the profound effects that non-ordinary states, particularly those induced by psychedelics, have on the brain. It highlights how psychedelics influence neural pathways, rerouting them to foster personal growth and address conditions like addiction and depression. Key mechanisms, such as the suppression of the default mode network (DMN), increased brain connectivity, and...
While problematic smartphone use screening tools are widely used and increasingly evaluated in student populations, their applicability and clinical stability across diverse groups-particularly those with comorbid substance use-remain unclear. Moreover, the overlap between problematic smartphone use and internet gaming disorder has not been well established in clinical contexts. This study...
Motives are a highly influential force in substance use and vary depending on the substance or dose being used. Little research has compared motives across different doses of psilocybin. Psilocybin is often ingested in microdoses (0.1–0.4 g) or macrodoses (1 g+), each producing unique perceptual and mood effects. The current study examined whether motives for microdose and macrodose psilocybin...
Retrospective study of 3,60916 person who were depend on Alcohol and tobacco.In this study we found the result of efficacy of rajyoga meditation very impressive.In this protocol we used early morning meditation, evening meditation before sleep,positive affirmation to mind, regular Murli class,traffic control l3-4 times for 3 minutes.(controland remove negative thoughts), charging water and...
Fa yi xue za zhiApril 25, 2025Yu-Meng Zuo, Wei Han, Jian-Bo Zhang et al.
Ketamine is a dissociative anesthetic. It is clinically used as a surgical anesthetic or anesthetic inducer and has a certain degree of mental dependence. Its abuse can lead to nerve damage, adverse emotional reactions and other toxic side effects. The primary mechanism by which ketamine exerts its pharmacological effects is to block N-methyl-D-aspartate receptors (NMDAR). It also functions...