The recreational use of nitrous oxide (N2O) has seen a worldwide rise in the recent years, resulting in an increased incidence of neurological complications due to N2O-induced functional vitamin B12 deficiency. Here, we report on a cohort of patients admitted to a tertiary care center with neurological symptoms in the context of recreational N2O use between 2020 and 2024. We screened the...
Nightmares and non-nightmare sleep disturbances are a core feature of posttraumatic stress disorder. Effective treatments remain elusive. Doxazosin is an alpha-1 adrenergic blocker with demonstrated promise, but there is a dearth of evidence from randomized controlled trials on its effectiveness. We report findings from a randomized, double-blind, placebo-controlled trial evaluating the...
Electroencephalography (EEG) has potential to provide a sensitive measure of the acute neurophysiological response to cannabis administration. As delta-9-tetrahydrocannabinol (THC; the psychoactive constituent of cannabis) can induce transient neurocognitive impairments that differ as a function of tolerance and dose, understanding the neural profile related to intoxication would be of great...
Abstract This is the first book to explore the use of psychedelic medicines in palliative care and addiction medicine. Bringing together a diverse team of palliative physicians, therapists, researchers, spiritual guides, and entrepreneurs, the book explores the history, cultural significance, science, and legal status of eight major psychedelic medications. Each medication holds fascinating...
May 1, 2025Eve E. Keighley, Dalia A Bedewy, Eid Abo Hamza et al.1 citation
preprint
Given the recent resurgence of using psychedelic drugs to treat substance misuse (SM), reviewing the latest information on their current status is essential. Substance use disorders (SUD) are psychiatric conditions that comprise the repetitive use of illicit substances, despite the harmful and damaging ramifications. Current treatment options for SUD are limited and have displayed low...
May 1, 2025Jessi Humphreys, Lou Lukas, Yvan Beaussant et al.
Abstract Psilocybin, a naturally occurring psychoactive compound found in more than 200 mushroom species, has an enduring history of use in sacred rituals of Indigenous healers worldwide. With selective serotonin receptor binding, activation of the serotonergic neurological system enables psilocybin to potentiate neuroplasticity, enabling individuals to engage in meaning-making from psychedelic...
This pilot study was the first of its kind to examine the experiences of people with persistent pain engaging in a six-week iRest for Pain group program as part of multidisciplinary pain care. The present study used a qualitative, phenomenological design and reflexive thematic analysis to gain an understanding of the firsthand experience of patients who participated in the iRest for Pain group...
Acta PsychologicaMay 1, 2025Fengbo Liu, Qingyang Yu, Shichang Cai et al.2 citations
To explore the impact of brief mindfulness training on athletes' mood and the moderating effect of burnout between them. This study has employed the mixed experimental design of 2 (experimental conditions) × 2 (time points), randomly assigned 60 athletes into a mindfulness training group and a control group (30 athletes in each group), and selected the Five Facets Mindfulness Questionnaire...
The drug development process in psychiatry faces significant challenges due to low reproducibility rates in animal testing, which often leads to translation failures. To address this issue, we introduce a new approach in psychiatric drug development: a preclinical randomized controlled trial (preRCT). To demonstrate its potential utility, we conducted a multi-center preRCT using the alcohol...