Human Psychopharmacology: Clinical and Experimental
September 1, 2025
Renée Martin-Willett, Carillon J. Skrzynski, Angela D Bryan et al.
This study examined the effects of tetrahydrocannabinol (THC) and cannabidiol (CBD) on negative mood and drinking behaviors, and whether those effects were moderated by levels of perceived discrimination among participants who identify with a racial, ethnic, gender, or sexual identity that is underrepresented in research. Participants were either not using cannabis, using cannabis with THC, or...
Philosophy, Psychiatry, & Psychology
September 1, 2025
David Zheng
abstract: Paul's concepts of "Transformative Experiences" (TE) has sparked extensive discussion on multiple epistemological and ethical issues within philosophy. In particular, Paul's work has inspired significant work on the possibility of informed consent with regard to medical interventions that may induce said TEs. One such intervention, namely Psychedelic-assisted Therapy (PAT), has been...
Drug Science, Policy and Law
September 1, 2025
David Nutt, David Erritzøe, Anne Katrin Schlag et al.
9 citations
Psychedelics are undergoing a clinical research renaissance, with compounds such as psilocybin advancing to Phase 3 trials for treatment-resistant depression and receiving fast-track or breakthrough designations from regulatory agencies. Despite this progress, the field lacks standardized terminology to guide clinical development, dosing, safety monitoring, and regulatory classification. Here,...
International Journal of Innovative Technologies in Social Science
September 1, 2025
Anna Blazhkova, Magdalena Czaja, Hanna Sitka et al.
Introduction: Recently, there has been a significant increase in interest in the use of psychedelics for various psychiatric conditions. Psilocybin is receiving particular attention as a psychoactive substance with significant therapeutic potential. Recent research focuses on its possible benefits in the treatment of major depressive disorders (MDD) and anorexia nervosa (AN). Purpose of the...
Physiology & Behavior
September 1, 2025
Yiru Dong, Sebastian Goodwin-Groen, Jessie Ma et al.
4 citations
The activity-based anorexia (ABA) animal model captures key maladaptive behaviors of anorexia nervosa - starvation-evoked hyperactivity, voluntary food restriction, severe weight loss and elevated anxiety-like behavior. By repeating ABA induction, the model reveals an animal's gain of resilience against ABA relapses and concomitant synaptic plasticity. We review findings on the efficacy of...
August 29, 2025
David A. Gorelick
The prevalence of cannabis-induced psychosis has increased substantially, possibly due to higher cannabis potency and greater use. Antipsychotic medication reduced hospitalization risk by 25% for psychosis, 25% for substance use disorders, and 50% for medical conditions. For psychosis-related hospitalization, long-acting injectable aripiprazole or olanzapine reduced risk by 75%—twice as...
August 29, 2025
Romesha Uduwawela
<p><strong>Psilocybin, the psychoactive compound found in certain mushrooms, has gained increasing attention for its potential therapeutic applications in mental health treatment. While clinical research highlights its efficacy in alleviating mental disorders, such as depression, anxiety, PTSD, and substance use disorders, much remains to be known about the role of acute doses of psilocybin...
Journal of Advances in Medicine and Medical Research
August 28, 2025
O. Ogundeji, Nkechinyere M Harry, Akinyemi Akinwumiju et al.
Major Depressive Disorder (MDD) affects approximately 280 million people globally, with current treatments showing significant limitations, including delayed onset of action, low remission rates, and troublesome side effects. Esmethadone (REL-1017, d-methadone) has emerged as a promising agent for MDD. This review examines esmethadone (REL-1017), a novel glutamatergic modulator functioning...
Contemporary Drug Problems
August 28, 2025
Jason K. Day, Michael Th. Grooff
1 citation
Established by the 1971 United Nations (UN) Convention on Psychotropic Substances, the prohibition of the recreational use of psychedelics (lysergic acid diethylamide [LSD], psilocybin, N , N -dimethyltryptamine [ N , N -DMT], and mescaline) has two premises. First, recreational use poses a serious threat to public health because psychedelics are highly liable to addiction and abuse. Second,...
TIPS - Trends in Pharmacological Sciences
August 28, 2025
Alex C. Kwan, John R. Mantsch, John D. Mccorvy
7 citations
There is growing interest in developing psychedelic-inspired drugs for treating psychiatric disorders. However, identifying next-generation psychedelic analogs with ideal receptor selectivity and true therapeutic efficacy remains a major challenge. Recent progress has been driven by advances in determining agonist-induced biased signal transduction, high-content behavioral phenotyping via...