ACS Chemical Neuroscience
September 3, 2025
Arabo A. Avanes, Hunter T Warren, Abinaya Senthil et al.
2 citations
Tropane alkaloids and their derivatives represent a diverse class of small molecules with a broad range of therapeutic applications. Many tropanes regulate synaptic levels of neuromodulators by interacting with monoamine transporters such as dopamine (DAT) and serotonin (SERT) transporters. While DAT inhibition plays an important role in the addictive potential of tropanes such as cocaine,...
Psychedelics
September 2, 2025
Gregor Hasler
Professor Gregor Hasler stands at the forefront of revolutionary psychedelic research and neuroplasticity studies, transforming our understanding of mental health treatment through groundbreaking scientific discoveries. As Chair of Psychiatry at the University of Fribourg, Switzerland, where he directs the Molecular Psychiatry Lab, Hasler has pioneered research on how psychedelics like LSD,...
Mindfulness
September 1, 2025
Marieke Rombouts, Johanna H. Lensen, Jannis T. Kraiss et al.
Abstract Objectives Few studies have examined why Mindfulness-Based Stress Reduction (MBSR) programs are effective among teachers. The aim of this study was to examine possible mediators underlying the effectiveness of an MBSR program for Dutch elementary school teachers. Methods Data of a randomized controlled trial (RCT) with intervention (n = 72) versus control group (n = 74) were used....
Behaviour Research and Therapy
September 1, 2025
M. Herbert, J. Fishbein, Mara Tynan et al.
Acceptance and commitment therapy (ACT) is an empirically-supported psychotherapy for chronic pain. Although mindfulness is a key component of ACT, most ACT protocols do not include formal mindfulness meditation practice as a principal treatment method, leaving open the question of whether formal practice may bolster ACT's effects. Addressing this gap, the present study assessed the feasibility...
American Journal on Addictions
September 1, 2025
Valerio Ricci, Domenico de Berardis, Giovanni Martinotti et al.
AbstractBackground and ObjectivesCannabis use is associated with psychotic disorder onset and exacerbation. This study examines how continued cannabis use affects depressive symptoms, psychotic symptoms, and suicidal behaviors following cannabis‐induced first‐episode psychosis (FEP).MethodsSixty‐five participants (aged 16–50 years) with FEP were recruited from psychiatric inpatient facilities...
Cureus
September 1, 2025
Selvaraj Giridharan, Soni Soumian, Nagaraj V Kumar et al.
Vipassana meditation, an ancient Buddhist-derived practice that emphasises insight through non-judgmental observation of sensations and thoughts, has gained popularity for its potential to enhance health and well-being. Building on earlier research, this updated review synthesises empirical evidence published since 2010 to evaluate the impact of Vipassana across the psychological,...
Biological Psychology
September 1, 2025
Norden E. Huang, Wei-Shuai Yuan, Albert C Yang et al.
Consciousness remains a multifaceted phenomenon that is difficult to be measured by traditional quantification methods. Here we propose the intrinsic probability density function (iPDF) as a quantitative method to evaluate the dynamic inter-cortical interactions that underlie conscious states. First, the method utilizes empirical mode decomposition to derive intrinsic mode functions (IMFs) from...
PLoS Computational Biology
September 1, 2025
Jordy Peeters, Dimitri de Bundel, Kenno Vanommeslaeghe
The serotonin-2A receptor (5-HT2AR) is an interesting target for drug design in the context of antidepressants that might have a rapid onset of action and/or be effective in treatment-resistant cases. The main challenge, however, is that the activation of this receptor can provoke hallucinations. Recent studies have shown that activating the receptor with certain (partial) agonists could...
The Journal of Clinical Psychiatry
September 1, 2025
Vania Modesto-Lowe, Deanna Sgambato, Pa-C Margaret Chaplin
To the Editor: Psychedelic-assisted therapy (PAT) combines psychedelics, such as psilocybin, with guided psychotherapeutic support. 1 These substances interact with patient's mindset ("set") and the surrounding environment ("setting"), 2 making the context of the experience a critical factor in therapeutic outcomes.As these substances gain recognition for their therapeutic potential, it is...
Cureus
September 1, 2025
Aditya Lal Vallath, Ratan P Yadav, Michelle Bass et al.
Nitrous oxide (N₂O), a dissociative anesthetic and analgesic, has seen a concerning rise in recreational abuse, particularly among adolescents and young adults. This resurgence is fueled by its easy accessibility in large-volume, flavored canisters marketed as cooking aids, which exploit legal loopholes, as well as its promotion through popular culture and social media platforms like TikTok and...