Although psychedelics have shown therapeutic potential in treating conditions such as depression, PTSD, and addiction, concerns remain regarding ethical practices, participant diversity, and the structural limitations of prevailing theoretical frameworks. This theoretical framework critically examines the dominant biopsychic model that underpins much of contemporary psychedelic research and...
After many years of stigma and neglect, there is a resurgence of interest in the therapeutic use of psychedelic drugs. Anecdotal and evidence-based reports indicate psychedelics as a possible treatment for depression, anxiety, PTSD, substance abuse, and other disorders resistant to conventional medical interventions. The available data, however, are limited and the use of psychedelic substances...
Ayahuasca is a traditional Amazonian brew composed of Psychotria viridis, containing N,N-dimethyltryptamine (DMT), and Banisteriopsis caapi, which includes harmala alkaloids such as harmine. Ayahuasca can produce potent psychoactive effects primarily due to DMT, whose metabolism is inhibited by harmine via monoamine oxidase-A enzymes. This inhibition increases DMT's systemic bioavailability,...
El Trastorno de Estrés Postraumático (TEPT) constituye un desafío clínico significativo debido a las altas tasas de resistencia a la farmacoterapia convencional y el abandono de las terapias tradicionales. Ante este escenario, el actual "renacimiento psicodélico" propone el uso controlado de sustancias psicoactivas como herramientas para potenciar el procesamiento del trauma. El objetivo de...
US-amerikanische Psychiater*innen untersuchten, inwieweit eine Behandlung mit Psilocybin bei Patient*innen mit Alkoholkonsumstörung Persönlichkeitsanomalien derart abschwächen kann, dass es zu einer Verringerung der Impulsivität mit weniger Alkoholkonsum kommt.
Neuro-OncologyNovember 1, 2025Richard Drexler, Belgin Yalçın, Rebecca Mancusi et al.
Abstract High-grade gliomas are the most aggressive form of brain tumors, and neuronal activity has emerged as a driver of glioma pathophysiology. Activity-dependent glioma growth results from paracrine factor signaling and bona fide neuron-to-glioma synapses that integrate glioma cells into brain-wide neuronal circuits. Here, we report how glioma cells integrate into serotonergic (5-HT)...
Preliminary evidence suggests that classic psychedelics may exert lasting positive effects on individuals' mood, cognition, and personality, but little is known about how these effects may differ across the lifespan. Emerging adulthood (18-29) is a critical developmental stage in which individuals transition from dependence on community institutions toward full independence. It is a time when...
Abstract This article argues that early Buddhist discourse in the Sutta Piṭaka construes peace not as mere emotional calm or social quietism but as the pacification (upasama) that culminates in nibbāna, the unconditioned. Reading key formulae “nibbānaṁ paramaṁ sukhaṁ,” “stilling of all formations” (sabbasaṅkhārasamatho), and epithets such as santi (peace) and khema (security) the study...
Psychedelics, including psilocybin, lysergic acid diethylamide, and dimethyltryptamine, and entactogens such as 3,4-methylenedioxymethamphetamine are being investigated for treatment-resistant depression, post-traumatic stress disorder, anxiety, and substance use disorders. These compounds act primarily through serotonin 5-HT2A receptor agonism (psychedelics) or monoamine release (MDMA),...
Mushrooms of the Amanita genus are considered among the most toxic, causing severe poisoning, often resulting in death. However, of the 707 described species within this genus, only around a dozen contain the toxic octapeptides classified as amanitotoxins and phallotoxins. While most representatives of the genus are considered inedible species, there are a few exceptions that are palatable...