Expert Opinion on Pharmacotherapy
September 25, 2026
Haley Beck, Jennifer N Clements
This commentary summarizes the pharmacologic rationale, emerging evidence, clinical considerations, and limitations of microdosing glucagon-like peptide-1 (GLP-1)-based therapies. Microdosing of single or dual GLP-1 receptor agonists (RAs) has emerged as an off-label strategy to improve tolerability, reduce cost, and expand access during periods of medication shortages. Although standard doses...
Frontiers in Psychiatry
September 24, 2026
Franziska Stadler, Johan Saelens, Ioline D. Henter et al.
Background: The past few decades have seen a revived interest in psychedelic-assisted and ketamine-assisted therapy for mental health disorders, but data concerning the acute, subacute, and long-term effects of serotonergic psychedelics on cognitive functioning are scarce. This international, online study (N = 759) sought to investigate the potential acute, subacute, and long-term effects of...
Filosofiya-Philosophy
September 23, 2026
Mariana Todorova
This article proposes the figure of the digital centaur – a contemporary transposition of the ancient hybrid form – as a conceptual and metaphoric instrument for thinking the human condition under the impact and pressures of artificial intelligence, neurotechnology, and emerging forms of synthetic sociality (humans and AI agents). The transhumanist horizon imagines a functional fusion: the...
PsyArXiv
September 23, 2026
Farzaneh Behzadi, Amir Kalantarifard, Dylan Chau Huynh et al.
preprint
Rhythm is a fundamental aspect of both architectural design and brain–body dynamics, yet research across these domains remains fragmented and largely descriptive. The absence of a shared conceptual framework limits systematic investigation of how architectural rhythms interact with human brain–body dynamics and may influence cognition and behavior. Drawing on enactivism and the concept of...
September 23, 2026
Jessica Annette Albrecht
This chapter examines the relationship between Buddhist meditation, psychology, and disability through a Global Religious History perspective. It argues that the modern understanding of Buddhist meditation as an emancipatory and universally accessible practice emerged within the late nineteenth- and early twentieth-century intersections of Orientalist scholarship, psychological science, and...
Research Square
September 23, 2026
Dana Kvietkute
preprint
Abstract Self-reflection has historically depended on temporal transformations that occurred automatically as life moved on: the past receded, what returned came back altered, the vantage from which it was encountered shifted, and other people changed alongside the person reflecting. Conversational AI decouples these transformations. A person continues to change while parts of the reflective...
Consciousness and Cognition
September 23, 2026
Zarah Le Houcq Corbi, Kathrin Koch, Alexander Soutschek
Theoretical accounts posit that mindfulness and metacognition are closely linked. We therefore tested the hypothesis that mindfulness training improves metacognitive sensitivity in value-based decision making as well as the (metacognition-dependent) ability to anticipate preference reversals. In a pre-registered study following a pre-test/post-test design, healthy participants performed tasks...
Zenodo (CERN European Organization for Nuclear Research)
September 23, 2026
Arthur Stewart
preprint
The six postulates of Integrated Information Theory 4.0 (IIT) (Albantakis et al., 2023) are jointly unsatisfiable, and not because the theory ranks them: the exclusion postulate contradicts itself in successive clauses, integration forbids what composition requires, and the one conflict the theory does adjudicate it adjudicates against itself, excluding from the Φ-structure the determinations...
Frontiers in Drug Discovery
September 23, 2026
Günther K. H. Zupanc, Abigail L. Zodl, Naya M. Sabha
Drug discovery notoriously suffers from high attrition rates during clinical trials. A major contributing factor to this issue is the frequent failure to identify adverse neural functional effects of compounds in the CNS at earlier stages of drug development than currently possible. To address this unmet need, the (side-)effects of the widely used antitussive dextromethorphan were assessed...
Journal of Psychoactive Drugs
September 23, 2026
Omer A. Syed, Rotem Petranker, Sean M. Nestor et al.
The use of ketamine as a treatment for mood disorders continues to grow in popularity. However, the differences between individuals consuming ketamine within clinical settings and those self-medicating in casual, non-clinical settings has not been yet characterized. Using the 2023 Global Psychedelic Survey, this study aimed to examine the demographic and clinical characteristics, as well as the...