Evidence for a central 5‐hydroxytryptamine receptor stimulation by lysergic acid diethylamide
N.‐e. Andén, H. Corrodi, Kjell Fuxé, Tomas Hökfelt
British Journal of Pharmacology September 1, 1968 DOI: 10.1111/j.1476-5381.1968.tb07943.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | Lysergic acid diethylamide (LSD) methysergide |
| Topics | LSD Serotonin |
| Keywords | Stimulation 5-HT Receptor 5-hydroxytryptophan Hallucinogen Dopamine Pharmacology Spinal cord Endocrinology Tryptophan hydroxylase Central nervous system |
| Citations | 274 |
| Key findings | LSD stimulates central serotonin receptors and reduces serotonin turnover in rat brain and spinal cord, likely through negative feedback mechanisms. |
Abstract
Lysergic acid diethylamide (LSD) and the 5‐hydroxytryptamine (5‐HT) precursor, 5‐hydroxytryptophan produced similar functional effects in rat spinal cord and brain to the 5‐hydroxytryptamine precursor 5‐hydroxytryptophan, which indicates that LSD stimulates central 5‐HT receptors. By means of combined histochemical and biochemical techniques it was found that LSD reduced the turnover rate of brain and spinal cord 5‐HT, studied after inhibition of the tryptophan hydroxylase by α‐propyldopacet‐amide. The turnover of brain noradrenaline but not dopamine was somewhat accelerated. The functional and chemical effects by LSD were related to dose and to time. They were not observed after the LSD analogues 2‐bromo‐LSD and methysergide. The retardation of the 5‐HT turnover by LSD may be due to negative feed‐back mechanisms evoked by direct stimulation of the central 5‐HT receptors.
Comparable studies
Other preclinical and animal studies on LSD, most cited first.
Citations in the library
Cited by 40
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- Drug-Induced Psychosis: How to Avoid Star Gazing in Schizophrenia Research by Looking at More Obvious Sources of Light Frontiers in Behavioral Neuroscience 2011
- Stereospecific binding ofd-lysergic acid diethylamide (LSD) to brain membranes: Relationship to serotonin receptors Brain Research September 1, 1975
- Antagonism of 5‐hydroxytryptamine by LSD 25 in the central nervous system: a possible neuronal basis for the actions of LSD 25 British Journal of Pharmacology October 1, 1970
and 35 more in the library