Subjective Reactions to Lysergic Acid Diethylamide (LSD-25)
Archives of General Psychiatry May 1, 1962 DOI: 10.1001/archpsyc.1962.01710230020003 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Intervention | Lysergic acid diethylamide (LSD-25) |
| Topics | LSD |
| Keywords | Hallucinogen |
| Citations | 41 |
| Key findings | LSD-25 induces a wide range of psychological alterations, including disturbances in ego functions, drive manifestations, and psychopathology, comparable to those seen in schizophrenia and altered states of consciousness. |
Abstract
Introduction Clinical and observational studies of the effects of lysergic acid diethylamide (LSD25) have aroused much interest in recent years because of the unusual nature of the alterations in functioning that have been observed. Many have seen a possible relationship between these alterations and the disturbances seen in schizophrenic syndromes or, more generally, under conditions of altered levels of consciousness, such as sleep deprivation, hypnosis, and sensory isolation, and have been stimulated to explore the effects of the drug in great detail.4,7,9,10,16-19The scope of possible change is wide and includes a variety of disturbances in ego functions, alterations in drive manifestations, and other psychopathology. These alterations have been conceptualized in a variety of ways. Savage,19for example, described changes in autonomic functioning, motor functioning, mood, conation, cognition, and sensorium. Disturbances in thought and speech, affect, perception, behavior and
Comparable studies
Other narrative reviews on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Study of a New Schizophrenomimetic Drug—Sernyl | 1959 | Review | |
| Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function. General population | 2019 | Integrative review | |
| The Pharmacology of Lysergic Acid Diethylamide: A Review | 2008 | Review | |
| Serotonin research: contributions to understanding psychoses | 2008 | Review | |
| ADVERSE REACTIONS TO PSYCHEDELIC DRUGS. A REVIEW OF THE LITERATURE | 1984 | Review |
Citations in the library
Cited by 16
- Dose-Response Study of N,N-Dimethyltryptamine in Humans Archives of General Psychiatry February 1, 1994
- Untoward Reactions to Lysergic Acid Diethylamide (LSD) Resulting in Hospitalization New England Journal of Medicine December 2, 1965
- Dreams, Hallucinogenic Drug States, and Schizophrenia: A Psychological and Biological Comparison Schizophrenia Bulletin 1983
- Hallucinogenic Drugs in Psychiatric Research and Treatment Perspectives and Prospects The Journal of Nervous and Mental Disease March 1, 1995
- An Animal Behavior Model for Studying the Actions of LSD and Related Hallucinogens Science November 12, 1976
and 11 more in the library
Cites 6
- LYSERGIC ACID DIETHYLAMIDE (LSD-25) American Journal of Psychiatry June 1, 1952
- Lysergic Acid Diethylamide (LSD-25): I. Physiological and Perceptual Responses The Journal of Psychology 1955
- EFFECTS OF MESCALINE AND LYSERGIC ACID (d-LSD-25) American Journal of Psychiatry February 1, 1952
- Model Psychoses Induced by LSD-25 in Normals A M A Archives of Neurology & Psychiatry June 1, 1956
- Progression of Effects of Lysergic Acid Diethylamide [LSD] Archives of Neurology And Psychiatry July 1, 1956
and 1 more in the library