Progression of Effects of Lysergic Acid Diethylamide [LSD]
Archives of Neurology And Psychiatry July 1, 1956 DOI: 10.1001/archneurpsyc.1956.02330250052007 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Intervention | Lysergic acid diethylamide (LSD-25) |
| Topics | LSD |
| Keywords | Pharmacology |
| Citations | 29 |
| Key findings | LSD-25 consistently causes physical symptoms but produces variable mental effects, including increased activity, emotional expression, psychopathology, and reliving of repressed experiences. |
Abstract
Introduction Since the Swiss chemist Hoffman, on April 16, 1943, accidentally discovered the mental effects of lysergic acid diethylamide (LSD-25), a great many experiments with the drug have been reported in various journals. Observations show most agreement in the area of physical subjective symptoms and unreality and least agreement in changes of mood and behavior. Tremor, nausea, dilation of pupils, perspiration, and changes in blood pressure have been consistently found. The observed mental effects have been more at variance. Busch and Johnson,1interested in LSD-25 as a possible therapeutic agent, have found it to cause increased activity, exhibition of emotion, and expression of psychopathology, with only short periods of confusion and occasional visual hallucinations. Similarly, Sandison, Spencer, and Whitelaw2emphasize reliving of repressed personal experiences resulting from nonselective disturbance of the unconscious. Savage,3in a clinical psychological study, has found the mood to be one of aggrandizement,
Comparable studies
Other narrative reviews on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Study of a New Schizophrenomimetic Drug—Sernyl | 1959 | Review | |
| Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function. General population | 2019 | Integrative review | |
| The Pharmacology of Lysergic Acid Diethylamide: A Review | 2008 | Review | |
| Serotonin research: contributions to understanding psychoses | 2008 | Review | |
| ADVERSE REACTIONS TO PSYCHEDELIC DRUGS. A REVIEW OF THE LITERATURE | 1984 | Review |
Citations in the library
Cited by 11
- Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects Biological Psychiatry November 29, 2014
- On the Use and Abuse of LSD Archives of General Psychiatry March 1, 1968
- Effect of Hallucinogens on Unconditioned Behavior Current Topics in Behavioral Neurosciences 2016
- An Animal Behavior Model for Studying the Actions of LSD and Related Hallucinogens Science November 12, 1976
- Lysergic acid diethylamide: a drug of ‘use’? Therapeutic Advances in Psychopharmacology March 23, 2016
and 6 more in the library
Cites 5
- The Therapeutic Value of Lysergic Acid Diethylamide in Mental Illness Journal of Mental Science April 1, 1954
- LYSERGIC ACID DIETHYLAMIDE (LSD-25) American Journal of Psychiatry June 1, 1952
- Lysergic Acid Diethylamide (LSD-25): I. Physiological and Perceptual Responses The Journal of Psychology 1955
- EFFECTS OF MESCALINE AND LYSERGIC ACID (d-LSD-25) American Journal of Psychiatry February 1, 1952
- Lysergic Acid Diethylamide (Lsd-25): Xi. Content Analysis of Clinical Reactions The Journal of Psychology July 1, 1955