EFFECTS OF MESCALINE AND LYSERGIC ACID (d-LSD-25)
Paul H. Hoch, James P. Cattell, Harry H. Pennes
American Journal of Psychiatry February 1, 1952 DOI: 10.1176/ajp.108.8.579 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Schizophrenic patients and normal individuals |
| Interventions | Mescaline Lysergic acid |
| Topics | LSD Mescaline Psilocybin |
| Keywords | Hallucinogen Pharmacology |
| Citations | 116 |
| Key findings | Mescaline and lysergic acid markedly aggravate mental symptomatology in schizophrenic patients and disorganize psychic integration more than in normals. |
Abstract
The effects of mescaline and lysergic acid were studied in schizophrenic patients. It was found that physiological changes were produced in these patients and that their mental symptomatology was markedly aggravated. The observations made with the above-mentioned drugs on normal individuals were compared with those seen in schizophrenic patients. Mescaline and lysergic acid are drugs that disorganize the psychic integration of a person. This disorganization is much more apparent in schizophrenics than in normals. The diagnostic, prognostic, and therapeutic use of these drugs is also discussed.
Comparable studies
Other observational and cohort studies on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psychedelics not linked to mental health problems or suicidal behavior: A population study Randomly selected United States adults | 2015 | Observational cohort | n = 135,095 |
| Long-lasting subjective effects of LSD in normal subjects Healthy participants | 2017 | Observational cohort | n = 16 |
| Psychological and cognitive effects of long-term peyote use among Native Americans. Navajo Native Americans aged 18-45 | 2005 | Observational cohort | n = 176 |
| Mescaline-induced psychopathological, neuropsychological, and neurometabolic effects in normal subjects: experimental psychosis as a tool for psychiatric research. Normal men who were volunteers | 1992 | Observational cohort | n = 12 |
| 2,5-Dimethoxy-4-methyl-amphetamine (STP): A New Hallucinogenic Drug Normal control volunteers | 1967 | Observational study |
Citations in the library
Cited by 47
- Psychiatry & the psychedelic drugs. Past, present & future. Neuropharmacology December 25, 2017
- The Therapeutic Potential of Psilocybin Molecules May 15, 2021
- Acute Effects of Drug Abuse in Schizophrenic Patients: Clinical Observations and Patients' Self-reports Schizophrenia Bulletin 1990
- Comparative acute effects of mescaline, lysergic acid diethylamide, and psilocybin in a randomized, double-blind, placebo-controlled cross-over study in healthy participants. Neuropsychopharmacology October 1, 2023
- Lysergic Acid Diethylamide (LSD-25): I. Physiological and Perceptual Responses The Journal of Psychology 1955
and 42 more in the library