EFFECTS OF MESCALINE AND LYSERGIC ACID (d-LSD-25)
Paul H. Hoch, James P. Cattell, Harry H. Pennes
American Journal of Psychiatry February 1, 1952 DOI: 10.1176/ajp.108.8.579 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Schizophrenic patients and normal individuals |
| Interventions | Mescaline Lysergic acid |
| Topics | LSD Mescaline Psilocybin |
| Keywords | Hallucinogen Pharmacology |
| Citations | 116 |
| Key findings | Mescaline and lysergic acid markedly aggravate mental symptomatology in schizophrenic patients and disorganize psychic integration more than in normals. |
Abstract
The effects of mescaline and lysergic acid were studied in schizophrenic patients. It was found that physiological changes were produced in these patients and that their mental symptomatology was markedly aggravated. The observations made with the above-mentioned drugs on normal individuals were compared with those seen in schizophrenic patients. Mescaline and lysergic acid are drugs that disorganize the psychic integration of a person. This disorganization is much more apparent in schizophrenics than in normals. The diagnostic, prognostic, and therapeutic use of these drugs is also discussed.