Behavioural Brain Research - The Consciousness Library

AI ethics in computational psychiatry: From the neuroscience of consciousness to the ethics of consciousness

Behavioural Brain Research December 1, 2021 Wanja Wiese, Karl Friston

Methods used in artificial intelligence (AI) overlap with methods used in computational psychiatry (CP). Hence, considerations from AI ethics are also relevant to ethical discussions of CP. Ethical issues include, among others, fairness and data ownership and protection. Apart from this, morally relevant issues also include potential transformative effects of applications of AI—for instance,...

DOI: 10.1016/j.bbr.2021.113704 Full text

Dynamic Reconfiguration of Human Brain Networks Across Altered States of Consciousness.

Behavioural Brain Research November 1, 2021 Haiyang Liu, Ke-Hui Hu, Yingjie Peng et al.

Consciousness is supported by rich neuronal dynamics to orchestrate behaviors and conscious processing can be disrupted by general anesthetics. Previous studies suggested that dynamic reconfiguration of large-scale functional network is critical for learning and higher-order cognitive function. During altered states of consciousness, how brain functional networks are dynamically changed and...

DOI: 10.1016/j.bbr.2021.113685

The effectiveness of (R)-ketamine and its mechanism of action differ from those of (S)-ketamine in a chronic unpredictable mild stress model of depression in C57BL/6J mice.

Behavioural Brain Research October 1, 2021 Anna Rafało-Ulińska, Agnieszka Pałucha-Poniewiera 46 citations

(S)-ketamine has been approved as a rapid-acting antidepressant drug (RAAD). Although ketamine has an advantage over classic antidepressants (ADs) due to its rapid action, it remains a controversial drug due to its undesirable effects. Behavioral studies indicate that another enantiomer of ketamine, namely, (R)-ketamine, has been proposed as a safer but still effective RAAD. However, these...

DOI: 10.1016/j.bbr.2021.113633

Ayahuasca, a psychedelic beverage, modulates neuroplasticity induced by ethanol in mice

Behavioural Brain Research August 23, 2021 Carolina Aparecida Faria Almeida, Antônio Alves Pereira-Júnior, Jéssica Gonçalves Rangel et al. 33 citations

Alcohol use disorder needs more effective treatments because relapse rates remain high. Psychedelics, such as ayahuasca, have been used to treat substance use disorders. Our study aimed to evaluate the effects of ayahuasca on ethanol-induced behavioral sensitization (EIBS). Swiss mice received 2.2 g/kg ethanol or saline IP injections every other day across nine days (D1, D3, D5, D7, and D9),...

DOI: 10.1016/j.bbr.2021.113546 Ayahuasca Dynorphin Striatum Pharmacology +5

Out of our heads: Addiction and psychiatric externalism.

Behavioural Brain Research February 1, 2021 Shane N Glackin, Tom Roberts, Joel Krueger 28 citations

In addiction, apparently causally significant phenomena occur at a huge number of levels; addiction is affected by biomedical, neurological, pharmacological, clinical, social, and politico-legal factors, among many others. In such a complex, multifaceted field of inquiry, it seems very unlikely that all the many layers of explanation will prove amenable to any simple or straightforward,...

DOI: 10.1016/j.bbr.2020.112936 Full text Addiction 4e cognition Extended mind Integrative framework +2

Investigating the role of 5-HT2A and 5-HT2C receptor activation in the effects of psilocybin, DOI, and citalopram on marble burying in mice

Behavioural Brain Research December 28, 2020 Anna U. Odland, Jesper L. Kristensen, Jesper T. Andreasen 60 citations

Psychedelic drugs acting as 5-hydroxyptryptamine 2A receptor (5-HT2AR) agonists have shown promise as viable treatments of psychiatric disorders, including obsessive-compulsive disorder. The marble burying test is a test of compulsive-like behavior in mice, and psychedelics acting as 5-HT2AR agonists can reduce digging in this test. We assessed the 5-HT2R contribution to the mechanisms of two...

DOI: 10.1016/j.bbr.2020.113093 Psilocybin Citalopram Hallucinogen Pharmacology +3

Anti-inflammatory activity of ayahuasca: therapeutical implications in neurological and psychiatric diseases

Behavioural Brain Research November 6, 2020 Marina Goulart Da Silva, Guilherme Cabreira Daros, Rafael Mariano de Bitencourt 21 citations

Ayahuasca is a decoction with psychoactive properties, used for millennia for therapeutic and religious purposes by indigenous groups and the population of amazonian countries. As described in this narrative review, it is essentially constituted by β-carbolines and tryptamines, and it has therapeutic effects on behavioral disorders due to the inhibition of the monoamine oxidase enzyme and the...

DOI: 10.1016/j.bbr.2020.113003 Ayahuasca Hallucinogen Neuroinflammation Monoamine oxidase +2

Acute serotonin 2A receptor activation impairs behavioral flexibility in mice.

Behavioural Brain Research October 1, 2020 Dionisio A Amodeo, Omron Hassan, Landon M. Klein et al. 25 citations

Serotonin 2A (5-HT2A) receptors are the primary site of action of hallucinogenic drugs and the target of atypical antipsychotics. 5-HT2A receptors are also implicated in executive function, including behavioral flexibility. Previous studies showed that 5-HT2A receptor blockade improved behavioral flexibility in rodent models related to autism spectrum disorder and schizophrenia. The current...

DOI: 10.1016/j.bbr.2020.112861 Full text Serotonin 5-ht2a Behavioral flexibility Probabilistic reversal learning

Cortical reorganization processes in meditation naïve participants induced by 7 weeks focused attention meditation training.

Behavioural Brain Research October 1, 2020 Lukas Lenhart, Ruth Steiger, Michaela Waibel et al.

Based on the evidence that meditation is associated with numerous beneficial effects on well-being and reduced stress-related symptoms, mindfulness-based techniques were increasingly implemented into psychotherapeutic programs. However, different meditation styles and the cross-sectional nature of most previous analyses resulted in a great variety of morphometric findings. The present study...

DOI: 10.1016/j.bbr.2020.112828 Full text Neuroplasticity Diffusion-weighted imaging Focused attention meditation Gray matter volume

Ketamine as a mental health treatment: Are acute psychoactive effects associated with outcomes? A systematic review.

Behavioural Brain Research August 17, 2020 Meryem Grabski, Anna Borissova, Beth Marsh et al.

Esketamine was recently licensed by the US Food and Drug Administration (FDA) and European Drug Agency (EDA) for use in treatment resistant depression (TRD), and further research indicates ketamine as a possible treatment in other mental health conditions. While the underlying mechanisms remain unclear, it has been hypothesised that ketamine's acute psychoactive effects may be associated with...

DOI: 10.1016/j.bbr.2020.112629 Full text Ketamine Mystical experience Dissociative effects Mental health +2

Overlap in the neural circuitry and molecular mechanisms underlying ketamine abuse and its use as an antidepressant.

Behavioural Brain Research February 13, 2020 S. Kokane, Ross J. Armant, Carlos A. Bolaños-Guzmán et al.

Ketamine, a dissociative anesthetic and psychedelic compound, has revolutionized the field of psychopharmacology by showing robust, and rapid-acting antidepressant activity in patients suffering from major depressive disorder (MDD), suicidal tendencies, and treatment-resistant depression (TRD). Ketamine’s efficacy, however, is transient, and patients must return to the clinic for repeated...

DOI: 10.1016/j.bbr.2020.112548 Full text

Ketamine reverses the impaired fear memory extinction and accompanied depressive-like behaviors in adolescent mice.

Behavioural Brain Research November 6, 2019 Mei-Dan Wei, Yuhong Wang, Kun Lu et al.

Post-traumatic stress disorder (PTSD) is a chronic and disabling condition arising after exposure to a severe traumatic event, which affects approximately eight percent of the population. The underlying neurobiology of PTSD, however, has only been partially understood. The exploration of fear memory and its extinction has been the subject to increase our understanding of PTSD. Our previous...

DOI: 10.1016/j.bbr.2019.112342

Long-lasting effects of repeated ketamine administration in adult and adolescent rats.

Behavioural Brain Research September 2, 2019 M L Shawn Bates, Keith A Trujillo

Initiation of ketamine use often occurs in adolescence, yet little is known about long-term consequences when use begins in this developmental period. The current experiments were designed to examine the effects of repeated exposure to ketamine in adolescence on behavior in adulthood. We examined locomotor activity, as well as cognitive function, in animals that received repeated administration...

DOI: 10.1016/j.bbr.2019.111928 Full text Addiction Ketamine Adolescence Cognition +2

Rodent ketamine depression-related research: Finding patterns in a literature of variability

Behavioural Brain Research August 13, 2019 Andrew J. Polis, Paul J. Fitzgerald, Pho J. Hale et al. 58 citations

Discovering that the anesthetic drug ketamine has rapidly acting antidepressant effects in many individuals with major depression is one of the most important findings in clinical psychopharmacology in recent decades. The initial report of these effects in human subjects was based on a foundation of rodent preclinical studies carried out in the 1990s, and subsequent investigation has included...

DOI: 10.1016/j.bbr.2019.112153

Beneficial effects of (R)-ketamine, but not its metabolite (2R,6R)-hydroxynorketamine, in the depression-like phenotype, inflammatory bone markers, and bone mineral density in a chronic social defeat stress model.

Behavioural Brain Research August 1, 2019 Zhongwei Xiong, Yuko Fujita, Kai Zhang et al.

Inflammatory bone markers may play a role in the antidepressant actions of (R)-ketamine in susceptible mice after chronic social defeat stress (CSDS). In this study, we compared the effects of (R)-ketamine and its final metabolite (2R,6R)-hydroxynorketamine (HNK) in depression-like phenotypes, inflammatory bone markers and bone mineral density (BMD) in CSDS susceptible mice. We measured plasma...

DOI: 10.1016/j.bbr.2019.111904

Anxiolytic and antidepressant effects of ACPA and harmaline co-treatment.

Behavioural Brain Research May 17, 2019 Mohaddeseh Ebrahimi-Ghiri, Mohammad Nasehi, Mohammad-Reza Zarrindast

Depression and anxiety disorders are among the most common illnesses and a close relationship between them has been found. Because the psychotropic effects and abuse liability of cannabis prevent its therapeutic application in depression and anxiety states, we decided to investigate the effects of the combination of ineffective doses of cannabinoid CB1 receptor agonist...

DOI: 10.1016/j.bbr.2019.02.034 Full text Β-carbolines

Ketamine improved depressive‐like behaviors via hippocampal glucocorticoid receptor in chronic stress induced‐ susceptible mice

Behavioural Brain Research May 1, 2019 Wei Wang, Le Liu, Xiu Yang et al.

HighlightsSusceptible mice showed depressive‐like behaviors upon chronic social defeat stress.Plasma corticosterone concentration might predict susceptibility to chronic stress.Abnormal glucocorticoid receptor expression was associated with susceptibility.Ketamine exerted antidepressant effect via normalizing HPA axis response. &NA; Chronic stress is an important factor for depression. Most...

DOI: 10.1016/j.bbr.2019.01.057

5-Methoxy-α-methyltryptamine (5-MeO-AMT), a tryptamine derivative, induces head-twitch responses in mice through the activation of serotonin receptor 2a in the prefrontal cortex.

Behavioural Brain Research February 1, 2019 Arvie Abiero, Chrislean Jun Botanas, Leandro Val Sayson et al. 17 citations

5-Methoxy-α-methyltryptamine (5-MeO-AMT) is a tryptamine derivative that is used recreationally because of its reported hallucinogenic and mood elevating effects. Studies suggest that the psychopharmacological effects of tryptamines involve serotonin receptor 2a (5-HTR2a) activation in the brain. The head-twitch response (HTR) is widely used as a behavioral correlate for assessing 5-HTR2a...

DOI: 10.1016/j.bbr.2018.07.020 Full text 5-methoxy-a-methyltryptamine Conditioned place preference Head-twitch response Self-administration +1

Mindfulness and dynamic functional neural connectivity in children and adolescents.

Behavioural Brain Research January 15, 2018 Hilary A Marusak, Farrah Elrahal, Craig A Peters et al.

Interventions that promote mindfulness consistently show salutary effects on cognition and emotional wellbeing in adults, and more recently, in children and adolescents. However, we lack understanding of the neurobiological mechanisms underlying mindfulness in youth that should allow for more judicious application of these interventions in clinical and educational settings. Using multi-echo...

DOI: 10.1016/j.bbr.2017.09.010 Full text Default mode network Meditation Independent components analysis Intrinsic connectivity +2

Anxiolytic-like effects of noribogaine in zebrafish.

Behavioural Brain Research July 14, 2017 Allan V. Kalueff, Aleksandra Kaluyeva, Émeline L. Maillet 21 citations

Noribogaine is the main psychoactive metabolite of the hallucinogenic drug ibogaine, and is a particularly interesting compound potentially useful to treat dependence and various psychiatric disorders. Here, we report the effects of noribogaine on anxiety and locomotion in zebrafish (Danio rerio), a new promising model organism in neurobehavioral and psychopharmacological research. Adult...

DOI: 10.1016/j.bbr.2017.05.008 Full text Noribogaine Anxiety management Zebrafish research Drug abuse treatment

Sex differences in psychotomimetic-induced behaviours in rats.

Behavioural Brain Research March 30, 2017 Andrea Gogos, Snezana Kusljic, Shane J Thwaites et al.

Animal model studies using equal numbers of males and females are sparse in psychiatry research. Given the marked sex differences observed in psychiatric disorders, such as schizophrenia, using both males and females in research studies is an important requirement. Thus the aim of this study was to examine sex differences in psychotomimetic-induced behavioural deficits relevant to psychosis. We...

DOI: 10.1016/j.bbr.2017.01.028 Full text Amphetamine Female Locomotor hyperactivity Phencyclidine +1

Effects of LSD on grooming behavior in serotonin transporter heterozygous (Sert⁺/⁻) mice.

Behavioural Brain Research 2016 Evan J. Kyzar, Adam Michael Stewart, Allan V. Kalueff

Serotonin (5-HT) plays a crucial role in the brain, modulating mood, cognition and reward. The serotonin transporter (SERT) is responsible for the reuptake of 5-HT from the synaptic cleft and regulates serotonin signaling in the brain. In humans, SERT genetic variance is linked to the pathogenesis of various psychiatric disorders, including anxiety, autism spectrum disorders (ASD) and...

DOI: 10.1016/j.bbr.2015.08.018 Full text Lysergic acid diethylamide Grooming Hallucinogens Serotonin transporter

Examining the reinforcement-enhancement effects of phencyclidine and its interactions with nicotine on lever-pressing for a visual stimulus.

Behavioural Brain Research September 15, 2015 Natashia Swalve, Scott T Barrett, Rick A Bevins et al.

Nicotine is a widely-abused drug, yet its primary reinforcing effect does not seem potent as other stimulants such as cocaine. Recent research on the contributing factors toward chronic use of nicotine-containing products has implicated the role of reinforcement-enhancing effects of nicotine. The present study investigates whether phencyclidine (PCP) may also possess a reinforcement-enhancement...

DOI: 10.1016/j.bbr.2015.05.043 Full text Nicotine Operant behavior Phencyclidine Rats +1

Unique and potent effects of acute ibogaine on zebrafish: the developing utility of novel aquatic models for hallucinogenic drug research.

Behavioural Brain Research 2013 Jonathan Cachat, Evan J. Kyzar, Christopher Collins et al. 112 citations

An indole alkaloid, ibogaine is the principal psychoactive component of the iboga plant, used by indigenous peoples in West Africa for centuries. Modulating multiple neurotransmitter systems, the drug is a potent hallucinogen in humans, although its psychotropic effects remain poorly understood. Expanding the range of model species is an important strategy for translational neuroscience...

DOI: 10.1016/j.bbr.2012.08.041 Full text Zebrafish model Zebrafish research Animal model Aquatic model +31

How we remember the stuff that dreams are made of: neurobiological approaches to the brain mechanisms of dream recall.

Behavioural Brain Research January 15, 2012 Luigi De Gennaro, Cristina Marzano, Carlo Cipolli et al.

Intrinsic and historical weaknesses delayed the spread of a sound neurobiological investigation on dreaming. Nevertheless, recent independent findings confirm the hypothesis that the neurophysiological mechanisms of encoding and recall of episodic memories are largely comparable across wakefulness and sleep. Brain lesion and neuroimaging studies converge in indicating that...

DOI: 10.1016/j.bbr.2011.10.017 Full text

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