Rodent ketamine depression-related research: Finding patterns in a literature of variability
Behavioural Brain Research August 13, 2019 Andrew J. Polis, Paul J. Fitzgerald, Pho J. Hale et al. 58 citations
Discovering that the anesthetic drug ketamine has rapidly acting antidepressant effects in many individuals with major depression is one of the most important findings in clinical psychopharmacology in recent decades. The initial report of these effects in human subjects was based on a foundation of rodent preclinical studies carried out in the 1990s, and subsequent investigation has included...