Acute serotonin 2A receptor activation impairs behavioral flexibility in mice.
Behavioural Brain Research October 1, 2020 Dionisio A Amodeo, Omron Hassan, Landon M. Klein et al. 25 citations
Serotonin 2A (5-HT2A) receptors are the primary site of action of hallucinogenic drugs and the target of atypical antipsychotics. 5-HT2A receptors are also implicated in executive function, including behavioral flexibility. Previous studies showed that 5-HT2A receptor blockade improved behavioral flexibility in rodent models related to autism spectrum disorder and schizophrenia. The current...