Scientific Reports
December 30, 2024
Chloé Gomez, Lynn Uhrig, Vincent Frouin et al.
2 citations
Decoding states of consciousness from brain activity is a central challenge in neuroscience. Dynamic functional connectivity (dFC) allows the study of short-term temporal changes in functional connectivity (FC) between distributed brain areas. By clustering dFC matrices from resting-state fMRI, we previously described "brain patterns" that underlie different functional configurations of the...
Scientific Reports
December 30, 2024
Reem M Alnemari, Maram H Abduljabbar, Yusuf S Althobaiti et al.
Ketamine is a dissociative anesthetic drug that is abused by teenagers and young adults, commonly for recreational purposes in dance clubs, to generate euphoria and dissociation, and sometimes employed as a date-rape drug. Herein, a highly sensitive, and environmentally friendly spectrofluorimetric method was developed for detection of ketamine in pharmaceutical and plasma samples. The...
Scientific Reports
December 28, 2024
Mei Chih Liao, Ming Sing Jessica Choi, Chak Hei Ocean Huang et al.
2 citations
Loneliness has been recognized as a pressing global health threat. Research shows that loneliness is associated with depressive symptoms, but less is known about what factors might influence this relationship. This study tested the hypothesis that mindfulness would buffer the association between loneliness and depressive symptoms. A total of 220 Chinese adults completed validated measures of...
Scientific Reports
December 28, 2024
Harriet de Wit, Evan Hahn, Shahd Smadi et al.
1 citation
Psychoactive drugs such as alcohol and stimulants are typically used in social settings such as bars, parties or small groups. Yet, relatively little is known about how social contexts affect responses to drugs, or how the drugs alter social interactions. It is possible that positive social contexts enhance the rewarding properties of drugs, perhaps increasing their potential for repeated use...
Scientific Reports
December 2, 2024
Sara Rodriguez-Moreno, Blanca Rojas, Pablo Roca
6 citations
Medical practice exposes physicians to numerous stressors, leading to high rates of psychological distress and burnout, a problem that begins during medical school. Scientific evidence suggests that promoting compassion among physicians could improve their well-being and promote patient-centered care. However, the mechanisms underlying these benefits remain unclear. This study aimed to examine...
Scientific Reports
November 30, 2024
Takayuki Niizato, Kotaro Sakamoto, Yoh-Ichi Mototake et al.
9 citations
Integrated information theory (IIT) assesses the degree of consciousness in living organisms from an information-theoretic perspective. This theory can be generalised to other systems, including those exhibiting criticality. In this study, we applied IIT to the collective behaviour of Plecoglossus altivelis and observed that the group integrity (Φ) was maximised at the critical state. Multiple...
Scientific Reports
November 21, 2024
Maximillian J. Wood, Rosalind McAlpine, Sunjeev K. Kamboj
Psychedelic substances are garnering renewed interest for their potential therapeutic applications, yet the mechanisms by which challenging experiences during psychedelic use contribute to positive outcomes remains poorly understood. Here we present a mixed-methods investigation into the strategies individuals employ to navigate difficult psychedelic experiences and their relationship to...
Scientific Reports
November 20, 2024
János Kállai, Orsolya Vincze, Rita Hargitai et al.
Empirical evidence suggests that body ownership and the sense of agency operate as an interactive system correlated with the level of consciousness during tasks involving modifications in body representation. This study sought to elucidate the nature of this association by documenting the verbal manifestations of this interaction. Specifically, the study aimed to reveal the role of a sense of...
Scientific Reports
November 14, 2024
Erin Wang, David S. Mathai, Natalie Gukasyan et al.
18 citations
Psychedelic-assisted therapy (PAT) with substances like psilocybin and MDMA has shown promise for conditions including depression and post-traumatic stress disorder. Psilocybin and MDMA may become approved medicines in the coming decade. This study assessed knowledge and attitudes regarding PAT among 879 U.S. healthcare professionals via anonymous online survey. Multivariable linear regression...
Scientific Reports
November 13, 2024
Davide Tanasi, Branko F Van Oppen de Ruiter, Fiorella Florian et al.
9 citations
This study presents a comprehensive multimodal analytical study of an Egyptian ritual Bes-vase, of the 2nd century BCE employing cutting-edge proteomics, metabolomics, genetics techniques, and synchrotron radiation-based Fourier Transformed Infrared microSpectroscopy (SR µ-FTIR) to characterize organic residues of its content. We successfully identified the presence of various functional,...
Scientific Reports
November 12, 2024
András Sárközy, Jonathan Robinson, Gyula Kovács
Polar angle asymmetries (PAAs), the differences in perceptual experiences and performance across different regions of the visual field are present in various paradigms and tasks of visual perception. Currently, research in this area is sparse, particularly regarding the influence of PAAs during perceptual illusions, highlighting a gap in visual cognition studies. We aim to fill this gap by...
Scientific Reports
November 6, 2024
Yan Zhang, Chu-Ke Wei, Ping Wang et al.
12 citations
Prenatal stress exerts long-term impact on neurodevelopment in the offspring, with consequences such as increasing the offspring's risk of depression in adolescence and early adulthood. S-ketamine can produce rapid and robust antidepressant effects, but it is not clear yet whether and how S-ketamine alleviates depression in prenatally stressed offspring. The current study incestigated the...
Scientific Reports
November 2, 2024
Marco Schlosser, Julie Gonneaud, Stefano Poletti et al.
2 citations
Understanding the factors that predict why some individuals perceive to respond more to meditation training than others could impact the development, efficacy, adherence levels, and implementation of meditation-based interventions. We investigated individual-level variables associated with self- and teacher-perceived responsiveness to longer-term meditation training. This study presents a...
Scientific Reports
October 26, 2024
Micah Alan Johnson, Ninette Simonian, Nicco Reggente
6 citations
In this randomized, controlled, and double-blind experiment with a relatively large sample (n = 262), a novel technique of audiovisual stimulation (AVS) was demonstrated to substantially improve self-reported mood states by reducing several negative affects, including anxiety and depression, and enhancing performance on mood-sensitive cognitive tasks. Most of the AVS effects were highly similar...
Scientific Reports
October 24, 2024
Ji-Xiang Wan, Si-Si Zeng, Zhi-Qiang Wu et al.
4 citations
The objective of this study is to investigate the effects of various doses of esketamine on the median effective concentration (EC50) of propofol required for inhibiting body movement during hysteroscopy. Additionally, this research aims to explore the pharmacodynamic interactions between esketamine and propofol. Prospective, double-blind, up-down sequential allocation study. Operating room,...
Scientific Reports
October 23, 2024
Natali D. Kisaki, Yasmim A. Serra, Isa R S Rodrigues et al.
Ayahuasca has been proposed as a treatment for substance use disorders. However, because of its hallucinogenic properties, studies investigating its abuse potential are needed. The aim of the present study was to investigate voluntary ayahuasca drinking in male mice using a two-bottle choice procedure. Male mice were exposed to two bottles, one of water and one of ayahuasca (0.01, 0.03 or 0.1...
Scientific Reports
October 18, 2024
Amit Olami, Leehe Peled-Avron
9 citations
This meta-analysis investigates the effect of classic psychedelic drugs on empathy and focuses on cognitive and emotional empathy measured using the Multifaceted Empathy Test (MET). Empathy entails the ability to understand and share the feelings of another and is a significant component of social interaction. Several studies have examined the effects of psychedelic drugs such as LSD,...
Scientific Reports
October 13, 2024
Oscar Véliz-García, Marcos Domic-Siede
3 citations
Psychedelics have a complex history marked by traditional use among indigenous cultures, early scientific interest, and subsequent prohibition. Despite their classification as controlled substances, recent decades have witnessed a resurgence of research into their therapeutic potential for various mental health conditions. However, most studies have focused on controlled clinical settings,...
Scientific Reports
October 8, 2024
Mathias Schneeweiss-Gleixner, Katharina Krenn, Mathias Petter et al.
3 citations
Data on cholestasis and biliary injury in patients with COVID-19 are scarce. The primary aim of this study was to evaluate the prevalence of cholestasis and factors associated with its development and outcome in critically ill patients with COVID-19 associated acute respiratory distress syndrome (ARDS). In this retrospective exploratory study, COVID-19 patients with ARDS admitted to an...
Scientific Reports
August 30, 2024
Yumiao Fu, Yifan Song, Yining Li et al.
14 citations
Currently, 280 million people worldwide experience depression, ranking it third in the global burden of disease. The incidence of depression has risen due to the COVID-19 pandemic, making it essential to examine evidence-based practices in reducing depressive symptoms during this unprecedented time. This systematic review and meta-analysis aim to analyze randomized controlled trials during the...
Scientific Reports
August 11, 2024
Lila Harris-Blum, Zachary Smith, Richard J. Ortiz et al.
9 citations
LSD is a hallucinogen with complex neurobiological and behavioral effects. Underlying these effects are changes in brain neuroplasticity. This is the first study to follow the developmental changes in brain structure and function following LSD exposure in periadolescence. We hypothesized LSD given during a time of heightened neuroplasticity, particularly in the forebrain, would affect cognitive...
Scientific Reports
August 2, 2024
Jennifer Mitchell, Nicky J. Mehtani, Mallory O. Johnson et al.
9 citations
Abstract As a proposed mediator between stigma-related stressors and negative mental health outcomes, HIV-related shame has been predictive of increased rates of substance use and difficulties adhering to antiretroviral treatment among people with HIV. These downstream manifestations have ultimately impeded progress toward national goals to End the HIV Epidemic , in part due to limited success...
Scientific Reports
July 30, 2024
Matthias Wagner, Alissa Wieczorek
9 citations
Ego-depletion describes a state of mind, where the capacity for self-control is temporarily depleted after a primary self-control action. The aim of this study was to investigate whether a brief virtual reality-based mindfulness breathing meditation with integrated biofeedback can be considered an effective strategy to counteract the detrimental effects of ego depletion on motor skill...
Scientific Reports
July 30, 2024
J. D. Griffin, K. M. J. Diederen, J. Haarsma et al.
5 citations
We used a probabilistic reversal learning task to examine prediction error-driven belief updating in three clinical groups with psychosis or psychosis-like symptoms. Study 1 compared people with at-risk mental state and first episode psychosis (FEP) to matched controls. Study 2 compared people diagnosed with treatment-resistant schizophrenia (TRS) to matched controls. The design replicated our...
Scientific Reports
July 17, 2024
Sara de la Salle, Hannes Kettner, Julien Thibault Lévesque et al.
21 citations
Recent clinical trials have found that the serotonergic psychedelic psilocybin effectively alleviates anxiodepressive symptoms in patients with life-threatening illnesses when given in a supportive environment. These outcomes prompted Canada to establish legal pathways for therapeutic access to psilocybin, coupled with psychological support. Despite over one-hundred Canadians receiving...