Scientific Reports - The Consciousness Library

Chain mediation of rumination and anxiety state between mindfulness and depressed mood in infertile women.

Scientific Reports April 23, 2025 Shiqi Luo, Biru Luo, Zihang Wei et al. 2 citations

The study aims to explore the relationship between mindfulness, rumination thinking, anxiety state, and depressed mood, and the chain mediating roles of rumination thinking and anxiety state in explaining how mindfulness influences depressed mood in infertile women. This cross-sectional study included 946 women with infertility from a maternal and child hospital in western China through...

DOI: 10.1038/s41598-025-99147-w Full text Anxiety Depression Mindfulness Infertility +1

Comprehensive analysis of 42 psilocybin-producing fungal strains reveals metabolite diversity and species-specific clusters.

Scientific Reports April 22, 2025 Jonathan Cohen, Liron Sulimani, Shiri Procaccia et al. 4 citations

Psilocybin-producing fungi have garnered attention due to accumulating evidence regarding the therapeutic potential of their principal component psilocybin. This diverse group of fungi harbors a wealth of less-studied metabolites, however, thus far most research has addressed them as a cohesive group. By optimizing an approach for extraction and analysis, we examined the metabolomes of 42...

DOI: 10.1038/s41598-025-97710-z Full text Dephosphorylation Fungal extraction Fungal metabolome Liquid chromatography +6

Development of a PBPK model of psilocybin/psilocin from Psilocybe cubensis (magic mushroom) in mice, rats, and humans.

Scientific Reports April 21, 2025 Nilubon Thaoboonruang, Ornrat Lohitnavy, Kimheang Ya et al. 4 citations

Psilocybin is an active alkaloid found in magic mushrooms (Psilocybe cubensis). It is classified as a Class I Psychoactive Substance due to its psychoactive properties. Recent research has suggested that psilocybin holds potential for treating major depressive disorder. The objective of this study was to develop a physiologically based pharmacokinetic (PBPK) model for psilocybin and its active...

DOI: 10.1038/s41598-025-98202-w Full text Magic mushrooms Psilocin Psilocybin Psilocybe cubensis +6

Effects of long-term mindfulness meditation training on attentional capacity in professional male fencer athletes.

Scientific Reports April 15, 2025 Hong Ding, Lei Zhang, Chao Ma et al. 9 citations

Attention is a crucial cognitive ability for sports performance. The current research aimed to investigate whether long-term mindfulness meditation (MM) intervention enhances male athletes' attentional function and alters the activity of brain regions related to attention. In this experiment, we recruited 47 professional male fencer athletes completed two main trials-an MM trial and a control...

DOI: 10.1038/s41598-025-97179-w Full text Cognition Fencer athletes Mindfulness meditation training Fnirs

The 50% effective dose of remimazolam combined with different doses of esketamine for painless gastroscopy.

Scientific Reports April 14, 2025 Li Zhao, Xuelei Zhou, Linlin Chen et al. 5 citations

Remimazolam is a novel benzodiazepine sedative that provides effective sedation, stable haemodynamics, and minimal adverse effects during intravenous general anaesthesia. The aim of this study was to determine the 50% effective dose (ED50) of remimazolam combined with different doses of esketamine for painless gastroscopy and to evaluate the efficacy and safety of this combination. This was a...

DOI: 10.1038/s41598-025-97649-1 Full text Esketamine Gastrointestinal endoscopy Median effective dose Painless gastroscopy +5

Physiological assessment of the psychological flow state using wearable devices.

Scientific Reports April 7, 2025 Melinda Rácz, Melinda Becske, Tímea Magyaródi et al.

Flow is the state of optimal experience which can lead to outstanding performance. Our study demonstrates the feasibility of detecting and monitoring flow using wearable devices. Twenty-eight Hungarian adults participated in the experiment. They played a game at different levels to induce flow and anti-flow states, which was tested with questionnaires. We measured electroencephalography (EEG),...

DOI: 10.1038/s41598-025-95647-x Full text Electroencephalography Motion tracking Photoplethysmography Psychological flow +2

Somatosensory false feedback biases emotional ratings through interoceptive embodiment.

Scientific Reports April 3, 2025 Joel Patchitt, Sarah N. Garfinkel, William H Strawson et al. 4 citations

Mismatches between perceived and veridical physiological signals during false feedback (FFB) can bias emotional judgements. Paradigms using auditory FFB suggest perceived changes in heart rate (HR) increase ratings of emotional intensity irrespective of feedback type (increased or decreased HR), implicating right anterior insula as a mismatch comparator between exteroceptive and interoceptive...

DOI: 10.1038/s41598-025-94971-6 Full text Emotion recognition False physiological feedback Insula Interoception +2

Local field potential changes during euthanasia may parallel with near death experience.

Scientific Reports April 3, 2025 Julieta Trejo, Kaitlin M Killian, Zhen Wang et al. 1 citation

A global experience that every human life meets is death. For several decades, individuals have reported their unique encounters with near-death experience (NDE), which has raised many unanswered questions. In the present experiment, we utilize continuous local field potential (LFP) during the euthanasia process to show the dynamic changes of frequency band power in four distinct regions of the...

DOI: 10.1038/s41598-025-92723-0 Full text Near-death experience Dying brain Local field potential Out-of-body experience +1

EEG oscillations reveal neuroplastic changes in pain processing associated with long-term meditation.

Scientific Reports March 27, 2025 Juliana Yordanova, Valentina Nicolardi, Peter Malinowski et al. 4 citations

The experience of pain is a combined product of bottom-up and top-down influences mediated by attentional and emotional factors. Meditation states and traits are characterized by enhanced attention/emotion regulation and expanded self-awareness that can be expected to modify pain processing. The main objective of the present study was to explore the effects of long-term meditation on neural...

DOI: 10.1038/s41598-025-94223-7 Full text Meditation EEG Pain-related oscillations

Preliminary pharmacokinetic and psychophysical investigations after controlled oral and inhalative consumption of hexahydrocannabinol (HHC)

Scientific Reports March 24, 2025 Lisa Höfert, Benjamin Franz, Cedric Groß et al. 2 citations

The semi-synthetic cannabinoid hexahydrocannabinol (HHC) has become a highly discussed topic in forensic toxicology since 2022 due to its legal availability at this time and its psychoactive effects. This study aimed to investigate the pharmacokinetics, effects, and immunological detectability of HHC after oral (25 mg HHC fruit gum) and inhalative (three puffs from HHC vape) consumption with...

DOI: 10.1038/s41598-025-93931-4 Full text Pharmacokinetics Pharmacology Cannabinoid Saliva +1

Neural representation of consciously seen and unseen information.

Scientific Reports March 6, 2025 Pablo Rodríguez-San Esteban, Jose A Gonzalez-Lopez, Ana B Chica

Machine learning (ML) techniques have steadily gained popularity in Neuroscience research, particularly when applied to the analysis of neuroimaging data. One of the most discussed topics in this field, the neural correlates of conscious (and unconscious) information, has also benefited from these approaches. Nevertheless, further research is still necessary to better understand the minimal...

DOI: 10.1038/s41598-025-92490-y Full text

Brain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18.

Scientific Reports February 26, 2025 Merav Catalogna, Ya'Ira Somerville, Nira Saporta et al. 6 citations

Late-life depression represents a significant health concern, linked to disruptions in brain connectivity and immune functioning, mood regulation, and cognitive function. This pilot study explores a digital intervention targeting mental health, brain health, and immune functioning in individuals aged 55-60 with subjective cognitive decline, elevated stress and depressive symptoms. Seventeen...

DOI: 10.1038/s41598-025-91457-3 Full text Digital training Il-18 Late-life depression Resting State FMRI +1

Cardiac effects of two hallucinogenic natural products, N,N-dimethyl-tryptamine and 5-methoxy-N,N-dimethyl-tryptamine.

Scientific Reports February 25, 2025 Joachim Neumann, Tobias Dietrich, Karyna Azatsian et al. 2 citations

It is unclear whether hallucinogenic tryptamine derivatives namely N,N-dimethyl-tryptamine (DMT) and 5-methoxy-N,N-dimethyl-tryptamine (5-MeO-DMT) exert positive inotropic effects in the human heart. Therefore, we measured the inotropic effects of these drugs in isolated left and right atrial preparations of mice that overexpress human 5-HT4 receptors (5-HT4-TG) and preparations from wild type...

DOI: 10.1038/s41598-025-91400-6 Full text Serotonin sign N,N-Dimethyl-Tryptamine DMT 5-ht4 receptor 5-Methoxy-N,N-Dimethyl-Tryptamine 5-MEO-DMT +8

Mindfulness-based stress reduction as perceived by individuals with pathological mental fatigue after an acquired brain injury.

Scientific Reports February 24, 2025 Gustaf Glavå, Birgitta Johansson

After acquired brain injury (ABI), some individuals suffer from long-term fatigue and emotional distress, which affects their work ability and daily life. Mindfulness-based stress reduction (MBSR) has shown promising results in quantitative studies as a complementary treatment for pathological mental fatigue (PMF) after ABI. This study aims to explore how people suffering from lasting PMF after...

DOI: 10.1038/s41598-025-90452-y Full text Mbsr Acquired brain injury Neurorehabilitation Pathological mental fatigue +1

Efficacy and safety of esketamine for emergency endotracheal intubation in ICU patients: a double-blind, randomized controlled clinical trial.

Scientific Reports February 19, 2025 Xue Zhang, Xin Zhao, Jiaxin Xu et al. 8 citations

Emergency endotracheal intubation in critically ill patients are dangerous procedures with a greater risk of severe hypotension The efficacy and safety of esketamine with sympathoexcitatory effects for rapid sequence induction in critically ill patients remain unclear. In this prospective double-blinded randomized controlled trial, adult patients were randomly assigned to receive either...

DOI: 10.1038/s41598-025-91016-w Full text Anesthesia induction Emergency endotracheal intubation Hypotension Intensive care +9

From relaxed beliefs under psychedelics (REBUS) to revised beliefs after psychedelics (REBAS).

Scientific Reports January 29, 2025 Richard J. Zeifman, Meg J. Spriggs, Hannes Kettner et al. 26 citations

The Relaxed Beliefs Under pSychedelics (REBUS) model proposes that serotonergic psychedelics decrease the precision weighting of neurobiologically-encoded beliefs. We conducted a preliminary examination of two psychological assumptions of REBUS: (a) psychedelics foster acute relaxation and post-acute revision of confidence in mental-health-relevant beliefs; which (b) facilitate positive...

DOI: 10.1038/s41598-023-28111-3 Full text Psilocybin therapy Cognitive flexibility Psychedelics Mental health

Enhancing proteasome activity by NMDAR antagonists explains their therapeutic effect in neurodegenerative and mental diseases.

Scientific Reports January 13, 2025 Fikret Sahin, Aslihan Gunel, Buse Turegun Atasoy et al. 10 citations

NMDAR antagonists, such as memantine and ketamine, have shown efficacy in treating neurodegenerative diseases and major depression. The mechanism by which these drugs correct the aforementioned diseases is still unknown. Our study reveals that these antagonists significantly enhance 20S proteasome activity, crucial for degrading intrinsically disordered, oxidatively damaged, or misfolded...

DOI: 10.1038/s41598-024-84479-w Full text Mental diseases N-methyl-d-aspartate receptor nmdar antagonists Neurodegenerative diseases Proteasome +5

Incidence and risk factors of postoperative delirium in elderly surgical patients 2023.

Scientific Reports January 9, 2025 Efrem Fenta, Diriba Teshome, Simegnew Kibret et al. 36 citations

Postoperative delirium has the potential to impact individuals of all age groups, with a significant emphasis on the elderly population. Its presence leads to an increase in surgical morbidity and mortality rates, as well as a notable prolongation of hospital stays. However, there is a lack of research regarding the prevalence, risk factors, and implications of postoperative delirium in...

DOI: 10.1038/s41598-024-84554-2 Full text Elderly patients Postoperative delirium Geriatric surgery Elderly care +2

Neuropsychological profiles of patients suffering from hallucinogen persisting perception disorder (HPPD): A comparative analysis with psychedelic-using and non-using controls

Scientific Reports December 31, 2024 Georg Leistenschneider, Tomislav Majić, Simon Reiche et al. 3 citations

Abstract Classic psychedelics like LSD and psilocybin are showing promising effects in treating certain psychiatric disorders. Despite their low toxicity and lack of an addictive potential, in some individuals, psychedelics can be associated with persisting psychological harms. Hallucinogen Persisting Perception Disorder (HPPD) is one of those complications, a rare disorder characterized by...

DOI: 10.1038/s41598-024-82216-x Full text Psilocybin Neuropsychology Hallucinogen Neuropsychological assessment +4

Deep learning models reveal the link between dynamic brain connectivity patterns and states of consciousness.

Scientific Reports December 30, 2024 Chloé Gomez, Lynn Uhrig, Vincent Frouin et al. 2 citations

Decoding states of consciousness from brain activity is a central challenge in neuroscience. Dynamic functional connectivity (dFC) allows the study of short-term temporal changes in functional connectivity (FC) between distributed brain areas. By clustering dFC matrices from resting-state fMRI, we previously described "brain patterns" that underlie different functional configurations of the...

DOI: 10.1038/s41598-024-76695-1 Full text

Application of a nucleophilic substitution rection for spectrofluorimetric quantification of ketamine in pharmaceutical and plasma matrices.

Scientific Reports December 30, 2024 Reem M Alnemari, Maram H Abduljabbar, Yusuf S Althobaiti et al.

Ketamine is a dissociative anesthetic drug that is abused by teenagers and young adults, commonly for recreational purposes in dance clubs, to generate euphoria and dissociation, and sometimes employed as a date-rape drug. Herein, a highly sensitive, and environmentally friendly spectrofluorimetric method was developed for detection of ketamine in pharmaceutical and plasma samples. The...

DOI: 10.1038/s41598-024-82427-2 Full text Date-rape drug Drug addiction Eco-friendly spectrofluorimetric method Super k +5

The moderating role of mindfulness in the relationship between loneliness and depressive symptoms.

Scientific Reports December 28, 2024 Mei Chih Liao, Ming Sing Jessica Choi, Chak Hei Ocean Huang et al. 2 citations

Loneliness has been recognized as a pressing global health threat. Research shows that loneliness is associated with depressive symptoms, but less is known about what factors might influence this relationship. This study tested the hypothesis that mindfulness would buffer the association between loneliness and depressive symptoms. A total of 220 Chinese adults completed validated measures of...

DOI: 10.1038/s41598-024-81462-3 Full text Depression Mindfulness Loneliness Moderator analysis +1

MDMA as well as amphetamine and alcohol increase feelings of social closeness in healthy adults.

Scientific Reports December 28, 2024 Harriet de Wit, Evan Hahn, Shahd Smadi et al. 1 citation

Psychoactive drugs such as alcohol and stimulants are typically used in social settings such as bars, parties or small groups. Yet, relatively little is known about how social contexts affect responses to drugs, or how the drugs alter social interactions. It is possible that positive social contexts enhance the rewarding properties of drugs, perhaps increasing their potential for repeated use...

DOI: 10.1038/s41598-024-82632-z Full text MDMA Alcohol Closeness Connectedness +7

Mechanisms of change in compassion-based programs for medical students.

Scientific Reports December 2, 2024 Sara Rodriguez-Moreno, Blanca Rojas, Pablo Roca 6 citations

Medical practice exposes physicians to numerous stressors, leading to high rates of psychological distress and burnout, a problem that begins during medical school. Scientific evidence suggests that promoting compassion among physicians could improve their well-being and promote patient-centered care. However, the mechanisms underlying these benefits remain unclear. This study aimed to examine...

DOI: 10.1038/s41598-024-81557-x Full text Compassion Distress Mediation Medical students +2

Information structure of heterogeneous criticality in a fish school.

Scientific Reports November 30, 2024 Takayuki Niizato, Kotaro Sakamoto, Yoh-Ichi Mototake et al. 9 citations

Integrated information theory (IIT) assesses the degree of consciousness in living organisms from an information-theoretic perspective. This theory can be generalised to other systems, including those exhibiting criticality. In this study, we applied IIT to the collective behaviour of Plecoglossus altivelis and observed that the group integrity (Φ) was maximised at the critical state. Multiple...

DOI: 10.1038/s41598-024-79232-2 Full text Heterogeneous criticality Integrated information theory

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