Among 4,270 Latin American adults who regularly use macrodoses of psychedelics, the most common substance is psilocybin mushrooms. Users are diverse and are motivated mainly by psychological and spiritual well-being. The findings highlight the need for informed, safe, and legal use frameworks for naturalistic psychedelic use in Latin America.
Among 4,810 Latin American adults from six countries, the most common first psychedelic macrodose was psilocybin mushrooms (57.6%), followed by LSD (33.3%) and MDMA (17.5%). Most used these substances for recreation (70.5%), with spiritual (21.6%) and therapeutic (5.2%) motivations less frequent. Consumption typically occurred in social settings, especially with friends (65.7%), and 9.1% used them alone. Psilocybin was linked to introspection and well-being, ayahuasca to mystical states, and MDMA to heightened empathy. Familiar environments were associated with more positive experiences. Although 86.3% continued use, the main reason for stopping was lack of opportunity, not negative outcomes.