Herta Flor

2 papers in the library · publishing 2015-2023

Papers

Independent contribution of polygenic risk for schizophrenia and cannabis use in predicting psychotic-like experiences in young adulthood: testing gene × environment moderation and mediation.

Psychological Medicine April 1, 2023 Laurent Elkrief, Bochao Lin, Mattia Marchi et al.

Cannabis use at age 16 is associated with psychotic-like experiences (PLEs) even after accounting for genetic risk for schizophrenia, according to an analysis of 1740 European adolescents from the IMAGEN cohort and replicated in 1223 individuals from a Dutch cohort. Polygenic risk scores for schizophrenia predicted both cannabis use and PLEs, and cannabis use remained a significant predictor of PLEs in models including genetic risk. However, no evidence was found that genetic risk mediates or moderates the cannabis–psychosis link. The findings suggest cannabis use is a risk factor for PLEs independent of genetic vulnerability to schizophrenia.

DOI: 10.1017/s0033291721003378 Full text Cannabis Polygenic risk score Psychosis risk Psychotic-like experience

Post-amputation pain is associated with the recall of an impaired body representation in dreams-results from a nation-wide survey on limb amputees.

PLoS One January 1, 2015 Robin Bekrater-Bodmann, Michael Schredl, Martin Diers et al.

About 22% of 3,234 unilateral limb amputees could not remember their body representation in dreams, 24% always dreamed of themselves as intact, and less than 3% always as impaired; nearly 35% had mixed dreams. Lower-limb amputation and the presence of phantom limb pain and residual limb pain were associated with recalling an impaired body representation in dreams, while non-painful phantom phenomena had no influence. The findings suggest complex interactions between physical body appearance and mental body representation, likely modulated by waking distress.

DOI: 10.1371/journal.pone.0119552 Full text