Ketamine exhibits superior efficacy compared to conventional antidepressants, yet its clinical application remains limited by dose-dependent side effects. Ascorbic acid (AA) augments ketamine's antidepressant-like effects, suggesting that AA co-administration with subtherapeutic ketamine doses may achieve optimal efficacy while improving safety. Since AA itself lacks independently clinical...
Objective: Transcranial ultrasound stimulation (TUS) has been reported to modulate neural activity and accelerate the recovery of consciousness in the propofol-anesthetized mice. Both the thalamus and frontal cortex play critical roles in anesthetic-induced transition of consciousness. Approach: Twenty-one male BALB/c mice were randomly divided into the Sham group (n=7), the TUS1 group (n=7)...
Remimazolam is a novel benzodiazepine sedative that provides effective sedation, stable haemodynamics, and minimal adverse effects during intravenous general anaesthesia. The aim of this study was to determine the 50% effective dose (ED50) of remimazolam combined with different doses of esketamine for painless gastroscopy and to evaluate the efficacy and safety of this combination. This was a...
Background: This study explores how personality traits and mindfulness facets interact to influence perceived stress, focusing on a Chinese adult sample. It aims to address gaps in understanding the combined effects of dispositional and mindfulness factors on stress. Methods: A sequential explanatory mixed-methods design was employed. In the quantitative phase, 637 Chinese adults completed...
Focused attention meditation (FAM) training has been shown to improve attention, but the neural basis of FAM on attention has not been thoroughly understood. Here, we aim to investigate the neural effect of a 2-month FAM training on novice meditators in a visual oddball task (a frequently adopted task to evaluate attention), evaluated with both ASL and BOLD fMRI. Using ASL, activation was...
We aimed to assess whether dynamic arterial spin labeling (dASL), a novel quantitative MRI technique with minimal contamination of subject motion and physiological noises, could detect the longitudinal effect of focused attention meditation (FAM) on resting-state functional connectivity (rsFC). A total of 10 novice meditators who recorded their FAM practice time were scanned at baseline and at...