Cardiac effects of two hallucinogenic natural products, N,N-dimethyl-tryptamine and 5-methoxy-N,N-dimethyl-tryptamine.
Scientific Reports February 25, 2025 Joachim Neumann, Tobias Dietrich, Karyna Azatsian et al. 2 citations
It is unclear whether hallucinogenic tryptamine derivatives namely N,N-dimethyl-tryptamine (DMT) and 5-methoxy-N,N-dimethyl-tryptamine (5-MeO-DMT) exert positive inotropic effects in the human heart. Therefore, we measured the inotropic effects of these drugs in isolated left and right atrial preparations of mice that overexpress human 5-HT4 receptors (5-HT4-TG) and preparations from wild type...
DOI: 10.1038/s41598-025-91400-6 (opens in new tab)
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Serotonin sign
N,N-Dimethyl-Tryptamine DMT
5-ht4 receptor
5-Methoxy-N,N-Dimethyl-Tryptamine 5-MEO-DMT
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