X Yu

Ibogaine blocked methamphetamine-induced hyperthermia and induction of heat shock protein in mice.

Brain Research March 27, 1999 X Yu, Syed Z. Imam, Glenn D. Newport et al. 17 citations

Body temperature changes and heat shock protein (HSP-72) induction in the caudate nucleus were studied in female C57BL/6N mice pretreated with ibogaine (50 mg/kg) and sacrificed 48 h. after a single dose of methamphetamine (20 mg/kg). Methamphetamine injection resulted in hyperthermia and induced HSP-72 expression, whereas treatment with ibogaine alone produced hypothermia. The ibogaine...