Effects of acute and chronic ketamine administration on spontaneous and evoked brain activity.
Brain Research 2025 Ernestas Cizus, Urte Jasinskyte, Robertas Guzulaitis 3 citations
Schizophrenia is believed to be, at least in part, a dysfunction of the glutamatergic system. In line with anatomical evidence, suppressing N-methyl-D-aspartate (NMDA) neurotransmission leads to symptoms that are characteristic of schizophrenia. Rodent models of schizophrenia often involve the acute application of NMDA antagonists, which produce both behavioural and brain activity changes that...