Ibogaine pretreatment dramatically enhances the dynorphin response to cocaine.
Brain Research November 13, 1999 DOI: 10.1016/s0006-8993(99)02017-x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats (implied by typical neuroscience methods, but not stated) |
| Interventions | Ibogaine Cocaine |
| Topics | Ibogaine |
| Keywords | Natural compound Cocaine addiction Stimulant Dynorphin Neurochemical Brain pathways Brain's reaction Brain processing Addiction treatment Anti-addiction potential Insights into addiction |
| Citations | 11 |
| Key findings | Ibogaine pretreatment dramatically enhanced cocaine-induced increases in dynorphin content in the striatum, substantia nigra, and nucleus accumbens, whereas ibogaine alone did not alter dynorphin levels. |
Abstract
Ibogaine (Endabuse) is a psychoactive indole alkaloid found in the shrub, Tabernanthe iboga, which has been used to treat stimulant addiction. Because ibogaine influences the activity of neurotensin systems, a dopamine-linked neuropeptide, the present study investigated if ibogaine also influences dynorphin (DYN) pathways. Unlike neurotensin responses, ibogaine alone did not alter DYN levels in the striatum, substantia nigra or nucleus accumbens. Interestingly, ibogaine pretreatment dramatically enhanced cocaine-induced increases in DYN content in these structures.