Ibogaine pretreatment dramatically enhances the dynorphin response to cocaine.
Brain Research November 13, 1999 DOI: 10.1016/s0006-8993(99)02017-x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats (implied by typical neuroscience methods, but not stated) |
| Interventions | Ibogaine Cocaine |
| Topics | Ibogaine |
| Keywords | Natural compound Cocaine addiction Stimulant Dynorphin Neurochemical Brain pathways Brain's reaction Brain processing Addiction treatment Anti-addiction potential Insights into addiction |
| Citations | 11 |
| Key findings | Ibogaine pretreatment dramatically enhanced cocaine-induced increases in dynorphin content in the striatum, substantia nigra, and nucleus accumbens, whereas ibogaine alone did not alter dynorphin levels. |
Abstract
Ibogaine (Endabuse) is a psychoactive indole alkaloid found in the shrub, Tabernanthe iboga, which has been used to treat stimulant addiction. Because ibogaine influences the activity of neurotensin systems, a dopamine-linked neuropeptide, the present study investigated if ibogaine also influences dynorphin (DYN) pathways. Unlike neurotensin responses, ibogaine alone did not alter DYN levels in the striatum, substantia nigra or nucleus accumbens. Interestingly, ibogaine pretreatment dramatically enhanced cocaine-induced increases in DYN content in these structures.
Comparable studies
Other preclinical and animal studies on ibogaine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Noncompetitive Functional Inhibition at Diverse, Human Nicotinic Acetylcholine Receptor Subtypes by Bupropion, Phencyclidine, and Ibogaine TE671/RD cells (human muscle-type nAChR) and SH-SY5Y neuroblastoma cells (human... | 1999 | In vitro study | |
| Degeneration of Purkinje cells in parasagittal zones of the cerebellar vermis after treatment with ibogaine or harmaline. Ibogaine- or harmaline-treated rats | 1993 | Experimental animal study | |
| Effects and aftereffects of ibogaine on morphine self-administration in rats. Rats | 1991 | Preclinical experimental study | |
| Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum. Rats | 1994 | Experimental study | |
| Glial Cell Line-Derived Neurotrophic Factor Mediates the Desirable Actions of the Anti-Addiction Drug Ibogaine against Alcohol Consumption Rats | 2005 | Experimental study |
Citations in the library
Cited by 4
- Analysis of toxic alkaloids in body samples. Forensic Science International March 10, 2009
- How toxic is ibogaine? Clinical Toxicology 2016
- Responses of the extrapyramidal and limbic substance P systems to ibogaine and cocaine treatments. European Journal of Pharmacology February 25, 2000
- Rare but relevant: Ibogaine and cardiovascular complications-prolonged QT interval and ventricular arrhythmias. Addiction January 20, 2026
Cites 7
- Inhibitory effects of ibogaine on cocaine self-administration in rats. European Journal of Pharmacology September 14, 1993
- A preliminary investigation of ibogaine: case reports and recommendations for further study. Journal of Substance Abuse Treatment 1994
- The putative anti-addictive drug ibogaine is a competitive inhibitor of [3H]MK-801 binding to the NMDA receptor complex. Psychopharmacology May 1, 1994
- Ibogaine reduces preference for cocaine consumption in C57BL/6By mice. Pharmacology, Biochemistry, and Behavior 1994
- Ibogaine antagonizes cocaine-induced locomotor stimulation in mice. Life Sciences 1992
and 2 more in the library