Camilo Rojas

DPP IV inhibitor blocks mescaline-induced scratching and amphetamine-induced hyperactivity in mice

Brain Research June 1, 2005 Susan Lautar, Camilo Rojas, Barbara S. Slusher et al. 23 citations

Dipeptidyl peptidase IV (DPP IV) is a ubiquitous membrane-bound enzyme that cleaves the two N-terminal amino acids from peptides with a proline or alanine residue in the second position from the amino end. Potential substrates for DPP IV include several neuropeptides, suggesting a role for DPP IV in neurological processes. We have developed a potent DPP IV inhibitor (IC50 = 30 nM),...