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Extending ketamine's antidepressant effects.

Kenji Hashimoto

Science (New York, N.Y.) May 8, 2025 DOI: 10.1126/science.adx4559 (opens in new tab)

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Study at a glance

AI-extracted from the abstract

Characteristics	Preclinical study Peer reviewed
Population	Animal models
Intervention	ketamine
Topics	Depression Ketamine Esketamine
Keywords	Mental health Pharmacology
Citations	9
Key points	Boosting the mTOR signaling pathway preserves the antidepressant response to ketamine.

Abstract

Boosting an intracellular signaling pathway preserves the antidepressant response to ketamine.

Enhanced ERK activity extends ketamine's antidepressant effects by augmenting synaptic plasticity. Science (New York, N.Y.) May 8, 2025 44 citations
Antidepressant-like effects of ketamine involve CX3CL1/CX3CR1 signaling-mediated synaptic plasticity in the mPFC Translational Psychiatry July 20, 2026
Neurotrophic mechanisms underlying the rapid and sustained antidepressant actions of ketamine. Pharmacology, Biochemistry and Behavior December 9, 2019 181 citations
Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2. Neuron May 1, 2022 78 citations
Signaling pathways underlying the rapid antidepressant actions of ketamine. Neuropharmacology January 2012

Explore topics

Depression Ketamine