Enhanced ERK activity extends ketamine's antidepressant effects by augmenting synaptic plasticity.
Science (New York, N.Y.) May 8, 2025 Z Zack Ma, Natalie J Guzikowski, Ji-Woon Kim et al. 44 citations
Repeated ketamine treatment to maintain a rapid antidepressant effect can lead to side effects over time, highlighting an unmet clinical need for sustaining this drug's antidepressant action from a single administration. Ketamine-induced synaptic potentiation at CA3-CA1 synapses has been proposed to be a key synaptic substrate for antidepressant action. Here, we found that ketamine-induced...