JavaScript is disabled in your browser. You can still read and search, but features like search previews, menus, and forms may not work until it's enabled.

No trip needed for psychedelics to lift mood?

Cathleen O'Grady

Science (New York, N.Y.) June 9, 2023 DOI: 10.1126/science.adj1031 (opens in new tab)

Relevant Not relevant

Study at a glance

AI-extracted from the abstract

Characteristics	Experimental study Peer reviewed
Keywords	Psychedelics Mental health Pharmaceutical research Drug development
Citations	2
Key findings	LSD and psilocin bind to antidepressant drug targets in the brain.

Abstract

LSD and psilocin molecules bind to antidepressant drug targets in the brain, study shows.

Lysergic acid diethylamide (LSD) as a discriminative cue: Drugs with similar stimulus properties Psychopharmacology 1972 49 citations
Relationships of psychotomimetic to anti-serotonin potencies of congeners of lysergic acid diethylamide (LSD-25) Psychopharmacology 1959 78 citations
Role of psilocybin in the treatment of depression Therapeutic Advances in Psychopharmacology October 27, 2016 37 citations
d-Lysergic acid diethylamide, psilocybin, and other classic hallucinogens: Mechanism of action and potential therapeutic applications in mood disorders. Progress in Brain Research 2018 95 citations
Cross tolerance between LSD and psilocybin Psychopharmacology 1961 137 citations