Hallucinogenic drugs like LSD, psilocybin, and DMT affect the brain by stimulating serotonin receptors, particularly 5-HT2A receptors, which likely causes their hallucinogenic effects. However, these drugs also act on the heart, potentially increasing the force of contraction and heart rate, and may lead to arrhythmias. This review examines the inotropic and chronotropic actions of bufotenin, psilocin, psilocybin, LSD, ergotamine, ergometrine, N,N-dimethyltryptamine, and 5-methoxy-N,N-dimethyltryptamine in the human heart.
This review examines how amphetamine and its congeners, both stimulant and hallucinogenic, can directly and indirectly harm the heart. Focusing on isolated human heart muscle preparations, the authors assess whether these drugs alter cardiac contractility and describe the underlying mechanisms. They conclude that such drugs can have cardiac side effects leading to morbidity and death. Based on the current knowledge, the authors propose specific areas for further research to better understand these effects.