Binding of Mescaline with Subcellular Fractions upon Incubation of Brain Cortex Slices with [14C] Mescaline
R. K. Datta, W Antopol Dagger, Jagat J. Ghosh
Study at a glance
AI-extracted from the abstract| Characteristics | In vitro experimental study Peer reviewed |
|---|---|
| Population | Brain cortex slices |
| Topics | Mescaline |
| Keywords | Incubation Cortex anatomy Microsome Methemoglobin Biochemistry Radiochemistry In vitro Pharmacology |
| Citations | 1 |
| Key findings | Mescaline permeates brain cortex slices and binds to subcellular fractions in a time-dependent, energy-requiring process. |
Abstract
Incubation of brain cortex slices in the presence of glucose resulted in the permeation of about 65% of [14C] mescaline into slices. Of this, about one-third radioactivity was bound with nuclei, mitochondria, microsomes, and ribosomes. Dialysis of subcellular fractions did not markedly reduce the amounts of radioactivity bound to the fractions. The permeation into slices and the binding of mescaline to subcellular fractions were fairly time-dependent, but were inhibited by the presence of potassium cyanide, or by the absence of glucose and by heating to 80 degrees C for 1 min.
Comparable studies
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| Lysergic Acid Diethylamide- and Mescaline-Induced Attenuation of the Effect of Punishment in the Rat Rats | 1976 | Experimental study | |
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