Enhancement of morphine antinociception by ibogaine and noribogaine in morphine-tolerant mice.
Pharmacology November 1, 1998 S Sunder Sharma, Hemendra N. Bhargava 17 citations
The effects of ibogaine, an alkaloid isolated form the bark of the African shrub, Tabernathe iboga, and noribogaine, a metabolite of ibogaine, on morphine antinociception were determined in male Swiss-Webster mice. Mice were rendered tolerant to morphine by implanting them with a pellet containing 25 mg of morphine base for 3 days. Placebo pellet-implanted mice served as controls. The...