The Effects of some Hallucinogens on Aggressiveness of Mice and Rats
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Isolated mice and rats |
| Interventions | LSD mescaline Sernyl |
| Topics | Mescaline |
| Keywords | Hallucinogen Pharmacology Psychotomimetic |
| Citations | 19 |
| Key findings | Mescaline strongly reduced aggressiveness in mice but not in rats, while LSD decreased aggressiveness in mice and Sernyl had dose-dependent effects on mouse aggression. |
Abstract
The action of LSD, mescaline and Sernyl® onthe aggressiveness of isolated mice and killing reaction ofrats was investigated. At some dose range, LSD decreased the aggressiveness on isolation time. Mescaline was a strong in mice but not in rats whileSernyl slightly decreased the killing reaction and decreasedor increased the aggressiveness of mice according to dose level.
Comparable studies
Other preclinical and animal studies on mescaline, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species. C57BL/6J mice | 2020 | Experimental study with dose-response experiments | |
| Brain mechanisms of hallucinogens and entactogens Humans and rats | 2001 | Review | |
| Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology Zebrafish (Danio rerio) | 2012 | Experimental study | |
| Lysergic Acid Diethylamide- and Mescaline-Induced Attenuation of the Effect of Punishment in the Rat Rats | 1976 | Experimental study | |
| Dihydrobenzofuran Analogues of Hallucinogens. 3. Models of 4-Substituted (2,5-Dimethoxyphenyl)alkylamine Derivatives with Rigidified Methoxy Groups Rats (trained to discriminate saline from LSD tartrate) and rat cortical and... | 1996 | In vivo drug discrimination assay and in vitro radioligand binding assay |
Citations in the library
Cited by 3
- Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology Progress in Neuro-Psychopharmacology and Biological Psychiatry January 10, 2012
- A COMPARISON OF THE EFFECT OF MESCALINE ON ACTIVITY AND EMOTIONAL DEFAECATION IN SEVEN STRAINS OF MICE British Journal of Pharmacology September 1, 1975
- Perspectives on zebrafish models of hallucinogenic drugs and related psychotropic compounds. ACS Chemical Neuroscience August 6, 2013