Frontiers in Psychiatry - The Consciousness Library

Characteristics and mental health of psychedelic mushroom and multi-psychedelic users relative to non-psychedelic users in American adults, 2020-2021.

Frontiers in Psychiatry 2025 Sofia Abramsky-Sze, Elliot Marseille, Richard Matzopoulos et al. 4 citations

Few population-based studies have examined associations between psychedelic use and mental health outcomes. This work describes characteristics of exclusive psychedelic mushroom use (referred to as PM use), PMs in combination with other psychedelic substances (multi-psychedelic or MP) use, and non-psychedelic use and explores mental health ratings in non-clinical settings. This work uses...

DOI: 10.3389/fpsyt.2025.1508811 Full text Anxiety Depression Psilocybin Magic mushrooms +6

Effectiveness of Mindfulness and Qigong Training for Self-Healing in patients with Hwabyung and depressive disorder: a randomized controlled trial.

Frontiers in Psychiatry 2025 Seok-In Yoon, Hui-Yeong Park, Chan Park et al. 3 citations

Hwabyung is a Korean culture-bound syndrome characterized by anger-related physical and psychological symptoms. Depressive disorder is a common mental disorder that occurs worldwide and is highly comorbid with Hwabyung. In traditional East Asian medicine, both Hwabyung and depression are associated with an imbalance in vital energy termed qi. Mindfulness induces psychosomatic balance, and...

DOI: 10.3389/fpsyt.2025.1508937 Full text Depressive disorder Anxiety Hwabyung Qigong +14

Esketamine for postoperative sleep disturbance: clinical evidence, mechanisms, and future directions.

Frontiers in Psychiatry 2025 Qijing Liu, Ying Liu, Qian Fu et al. 2 citations

Postoperative sleep disturbance (PSD) is a common complication following surgery. Numerous factors can contribute to PSD, including personal factors, intraoperative factors, postoperative complications and environmental factors. PSD can lead to a range of adverse outcomes, severely impairing patients' postoperative recovery and long-term prognosis. Esketamine, a non-competitive...

DOI: 10.3389/fpsyt.2025.1612230 Full text Esketamine Nmda receptor antagonist Postoperative sleep disturbance Sleep quality +15

Ketamine treatment for buprenorphine-precipitated opioid withdrawal: a case report.

Frontiers in Psychiatry 2025 Ezioma Gbujie, Lisa Vercollone, Joji Suzuki 2 citations

The presence of fentanyl in the drug supply is thought to contribute to the incidence of buprenorphine-precipitated opioid withdrawal (BPOW) during initiation. Long used as a surgical anesthetic and an analgesic, the utility of ketamine for psychiatric and substance use disorder indications continues to grow. We present a case of intravenous (IV) ketamine use on the general medical floor for...

DOI: 10.3389/fpsyt.2025.1586945 Full text Buprenorphine opioid withdrawal Fentanyl Opioid withdrawal treatment Opioid withdrawal management +10

Brain stimulation enhances dispositional mindfulness in PTSD: an exploratory sham-controlled rTMS trial.

Frontiers in Psychiatry 2025 Kaveh Rayani, Andrea Grabovac, Peter Chan et al. 2 citations

Post-traumatic stress disorder (PTSD) is characterized by hypervigilance, intrusive thoughts, negative mood, and avoidant behaviors. Therapies involving mindfulness have been shown to reduce PTSD symptoms and modulate brain function. Pharmacological and brain stimulation interventions are also effective for treating PTSD. Non-invasive repeated transcranial magnetic stimulation (rTMS) of the...

DOI: 10.3389/fpsyt.2025.1494567 Full text PTSD Mindfulness Ffmq Dorsolateral prefrontal cortex +1

Effect of mindfulness group therapy on maternal psychological distress and perinatal outcomes in twin pregnancy: a randomized controlled trial.

Frontiers in Psychiatry 2025 Ying Zhou, Zai-Mei Tang, Lin Mei et al. 2 citations

Psychosocial stress, depression, and anxiety are prevalent during pregnancy and can be associated with adverse birth outcomes. This study aimed to evaluate the effectiveness of an online Mindfulness Group Therapy (MGT) program in improving perinatal maternal psychological distress and perinatal outcomes among women with twin pregnancies. In this randomized controlled trial, 120 women carrying...

DOI: 10.3389/fpsyt.2025.1572633 Full text Perinatal outcomes Twin pregnancies Expecting twins Mindfulness therapy: mindfulness +7

Body mass index is associated with the antidepressant effects of intravenous ketamine in patients with depression.

Frontiers in Psychiatry 2025 Jian-Qiang Tan, Li-Mei Gu, Yan-Ling Zhou et al. 2 citations

We aimed to explore the correlation between baseline body mass index (BMI) and the antidepressant properties of intravenous ketamine in patients with depression. We divided 135 patients diagnosed with either major depressive disorder (n=103) or bipolar depression (n=32) into lower and higher BMI groups based on their baseline BMI. Patients with a lower BMI (BMI0.05). The linear mixed models...

DOI: 10.3389/fpsyt.2025.1498952 Full text Major depressive disorder Mdd Bipolar depression Body mass index +6

Biological treatments for co-occurring eating disorders and psychological trauma: a systematic review.

Frontiers in Psychiatry 2025 Ella van Beers, Irene de Vries, Caroline Planting et al. 2 citations

Many people with eating disorders report having experienced childhood maltreatment or a traumatic event prior to developing an eating disorder. Although many people with eating disorders have significant traumatic exposure or symptoms of post-traumatic stress disorder, very little research has examined the effects of combined treatments for this group. The purpose of this systematic review was...

DOI: 10.3389/fpsyt.2025.1523269 Full text MDMA Post-traumatic stress disorder Bulimia nervosa Binge eating disorder +6

Case Report: Successful management of psychogenic non-epileptic seizures with intranasal esketamine.

Frontiers in Psychiatry 2025 Muneeb Hashmi, Padmasini Mugunthan, Priyal Jain et al. 2 citations

Psychogenic non-epileptic seizures (PNES), or functional seizures (FS), are episodes that resemble epileptic seizures but may be psychological in origin. Unlike epileptic seizures, which are linked to abnormal electrical activity in the brain, functional seizures may be associated with psychological and/or physical distress, and do not show the same electrical patterns on an...

DOI: 10.3389/fpsyt.2025.1527166 Full text Anxiety Esketamine Post-traumatic stress disorder Functional seizures +7

Treatment of neuropathic pain with repeated low-dose MDMA: a case report.

Frontiers in Psychiatry 2025 Peter Gasser, Matthias E. Liechti, Friederike Holze 2 citations

A 64-year-old male patient who suffered from traumatic life experiences and neuropathic pain after oncological chemotherapy was treated with medium to high doses of lysergic acid diethylamide (LSD) and high doses and microdoses of methylenedioxymethamphetamine (MDMA). At the beginning of treatment, the patient did not experience any acute subjective effects of LSD at a dose of 200 µg. After...

DOI: 10.3389/fpsyt.2025.1513022 Full text LSD Psychedelic-assisted therapy Psychedelic medicine Chronic pain treatment +4

Bringing MDMA-assisted therapy for PTSD to traditional healthcare systems: tending to set and setting.

Frontiers in Psychiatry 2025 Dimitri Perivoliotis, Kayla Knopp, Shannon Remick et al. 2 citations

Although effective evidence-based trauma-focused psychotherapies for posttraumatic stress disorder (PTSD) are available, a significant proportion of patients show a suboptimal response or do not complete them. MDMA-assisted therapy (MDMA-AT) for PTSD is a promising intervention currently being evaluated in numerous studies worldwide, including investigation for potential Food and Drug...

DOI: 10.3389/fpsyt.2025.1433999 Full text Psychedelic-assisted psychotherapy MDMA-Assisted Therapy Implementation Psychedelics +6

Virtual reality and psychedelics: new perspectives and new possibilities in the treatment of alcohol use disorder.

Frontiers in Psychiatry 2025 Scott Matthews, Antonino Greco, Clara Rastelli et al. 1 citation

Psychedelic-assisted therapy is a remarkably promising treatment for substance use disorders and for alcohol use disorder (AUD) in particular. Research supporting psychedelics as a safe and effective pharmacotherapy for AUD and its comorbid psychiatric conditions dates from the late1940s and includes over 2,000 published studies. There are, however, challenges to the clinical implementation of...

DOI: 10.3389/fpsyt.2025.1448043 Full text Deepdream Psychedelic phenomenology Psychedelic placebo Virtual reality

Research trends in esketamine for depression over the past decade: a bibliometric analysis.

Frontiers in Psychiatry 2025 Baozhou Zhang, Yifan Liu, Jinwei Zheng et al. 1 citation

Patients suffering from depression frequently encounter extended periods of low moods and lack of enjoyment or enthusiasm for activities. It leads to suicidal thoughts and presents a potential hazard to their safety. Nowadays, there has been significant progress in researching the effectiveness and safety of esketamine in treating depression. Hence, this paper employs bibliometric analysis to...

DOI: 10.3389/fpsyt.2025.1621830 Full text Bibliometric analysis Research trend Esketamine research esketamine Studies +9

A guided internet-delivered mindfulness-based cognitive therapy for insomnia: study protocol for a randomized controlled study.

Frontiers in Psychiatry 2025 Zixuan Zeng, Fei Liu, Chenyi Zhu et al. 1 citation

Chronic insomnia disorder (CID) is highly prevalent and impacts individuals' physiological, psychological and social functions. Although cognitive behavioral therapy for insomnia (CBT-I) is the recommended first-line treatment option for CID, approximately 20% of patients still exhibit limited effectiveness. The literature has shown that mindfulness can benefit CBT-I protocols and that...

DOI: 10.3389/fpsyt.2025.1506183 Full text Internet-based intervention Cognitive behavioral therapy Randomized controlled trial Insomnia treatment +4

Rapid treatment center for depression in China: constructive reflections and transnational implications.

Frontiers in Psychiatry 2025 Zhan-Ming Shi, Xing-Bing Huang, Yan-Ling Zhou et al. 1 citation

Enhancing the early diagnosis and standardized treatment of major depressive disorder (MDD), as advocated by the National Health Commission of China, is a key priority in the mental health initiatives of the nation. To achieve this, numerous evidence-based rapid treatment centers for MDD have been established or are currently under development across the country. These centers focus on the...

DOI: 10.3389/fpsyt.2025.1582312 Full text Esketamine nasal spray Major depressive disorder Stanford neuromodulation therapy Electroconvulsive therapy +11

Case Report: Intranasal esketamine combined with a form of generative artificial intelligence in the management of treatment-resistant depression.

Frontiers in Psychiatry 2025 Alexandre Fraichot, Sophie Favre, Hélène Richard-Lepouriel 1 citation

Intranasal Esketamine is an effective rapid-acting antidepressant currently used to treat treatment-resistant depression. Artificial intelligence is another emerging tool in medicine, but little is known about the effectiveness of combining these innovations in psychiatry. This case report presents the outcome of a 37-year-old patient who received intranasal Esketamine treatment (84 mg) and...

DOI: 10.3389/fpsyt.2025.1536232 Full text Treatment-resistant depression Artificial intelligence Case report Intranasal esketamine

Autism and schizophrenia spectrum disorder: phenomenological qualitative study of patients' experience.

Frontiers in Psychiatry 2025 Aleksandra Jeličić, Maja Drobnič Radobuljac, Louis Sass et al. 1 citation

Autism spectrum disorder (ASD) and schizophrenia spectrum disorder (SSD) overlap in behavioral signs, particularly in social functioning; consequently, SSD patients are frequently misdiagnosed with ASD and vice versa. The neurodevelopmental and spectrum nature of both disorders, including milder variants, further complicates differential diagnosis, which calls for a better differentiation by...

DOI: 10.3389/fpsyt.2025.1669930 Full text Autism spectrum disorder First-person perspective Intersubjectivity Ipseity disorder +1

Association between S-ketamine induced changes in glutamate levels in the pregenual anterior cingulate cortex and plasma brain-derived neurotrophic factor in healthy subjects.

Frontiers in Psychiatry 2025 Leonard Marx, Zümrüt Duygu Sen, Lena Vera Danyeli et al.

Ketamine's antidepressant effects have been linked to its modulation of glutamatergic neurotransmission and synaptic plasticity. However, the precise roles of both glutamate (Glu) levels and brain-derived neurotrophic factor (BDNF) in this process remain incompletely understood. This study examined the relationship between ketamine-induced changes in Glu levels and peripheral BDNF levels using...

DOI: 10.3389/fpsyt.2025.1662051 Full text Anterior cingulate cortex Brain-derived neurotrophic factor Magnetic resonance spectroscopy Ketamine antidepressant ketamine +8

Self-disturbance in first-episode psychosis: Theoretical framework and potential cannabis interactions - a systematic review.

Frontiers in Psychiatry 2025 Valerio Ricci, Domenico de Berardis, Giovanni Martinotti et al.

Cannabis use represents a significant environmental risk factor for psychotic disorders, with emerging evidence suggesting complex interactions between cannabinoid exposure, dissociative experiences, and fundamental disturbances of self-experience (self-disorders) in early psychosis. This systematic review examines the phenomenological and neurobiological relationships among dissociation,...

DOI: 10.3389/fpsyt.2025.1733254 Full text Cannabis Anomalous self-experience Depersonalization Dissociation +4

Psychological and neuropsychological effects of MDMA use during adolescence: a structured review.

Frontiers in Psychiatry 2025 Rocco Miazzi, Clara Cestonaro, Silvia Righetto et al.

This structured review critically examines the psychological and neuropsychological effects of MDMA (3,4-methylenedioxymethamphetamine) use during adolescence, focusing exclusively on human studies. MDMA is a widely consumed psychoactive substance among adolescents, particularly in social and recreational contexts. Drawing on 14 eligible studies identified through a comprehensive literature...

DOI: 10.3389/fpsyt.2025.1644599 Full text MDMA Adolescence Cognitive impairment Neuroimpact +1

The perspectives of patients with depression toward esketamine, and the influence of their medication adherence on their viewpoints: a Saudi cross-sectional study.

Frontiers in Psychiatry 2025 Ahmad H Almadani, Ayedh H Alghamdi, Fahad B Alfahad et al.

Nasal esketamine has demonstrated efficacy in the management of treatment-resistant depression and psychiatric emergency due to major depression. This study investigates acceptance and awareness of esketamine as a depression treatment option, focusing on factors that influence patients' acceptance, including adherence to current medication regimens, regardless of prior esketamine exposure. This...

DOI: 10.3389/fpsyt.2025.1678119 Full text Depression Esketamine Saudi arabia Perspectives +1

Low-dose intravenous esketamine on a depressive catatonia patient with venous thromboembolism: a case report.

Frontiers in Psychiatry 2025 Meng-Han Zhang, Yi-Fan Wang, Juan Li et al.

Catatonia is a rare but potentially life-threatening psycho-motor syndrome. It is mainly manifested as decreased activities, or excessive and specific activities, such as stupor, agitation and defiance. Catatonia can appear in various diseases and the diagnosis and treatment of depressive catatonia are often delayed. As an N-methyl-D-aspartate (NMDA) receptor antagonist, esketamine shows...

DOI: 10.3389/fpsyt.2025.1688633 Full text Major depressive disorder N-methyl-d-aspartate receptor antagonist Venousthromboembolism Catatonia treatment +1

Corrigendum: Ayahuasca-induced personal death experiences: prevalence, characteristics, and impact on attitudes toward death, life, and the environment.

Frontiers in Psychiatry 2025 Jonathan David, José Carlos Bouso, Maja Kohek et al. correction

1. In the published article, there was an error. The error was regarding the average number of ayahuasca uses in the ayahuasca group in Study 1. A correction has been made to the Results section in lines 387-390. This sentence previously stated:Briefly, on average, our study participants have used ayahuasca (mean = 69.4 ± 98.7), 6.4 times more than psilocybin (mean = 10.7 ± 15.4, U = 1378, p <...

DOI: 10.3389/fpsyt.2025.1595067 Full text Ayahuasca Coping Environmental concern Life fulfillment +10

PolDrugs 2025: results of the third edition of the nationwide study on psychoactive substance use in the context of psychiatry and harm reduction.

Frontiers in Psychiatry 2025 Julia Marek, Magdalena Domek-Gumprecht, Agata Macionga et al.

PolDrugs is a biennial epidemiological study aimed at analyzing patterns of mostly illicit psychoactive substance use in Poland in the context of psychiatry and harm reduction. This survey was held for the third time, and its results were compared to the last two editions. The survey was conducted as an online survey with 37 closed-ended single-choice questions and 3 multiple-choice questions....

DOI: 10.3389/fpsyt.2025.1591658 Full text DMT MDMA Marijuana Psilocybin +3

Acceptance and commitment therapy for psychiatric inpatients diagnosed with depression and insomnia: a multiple-baseline single-case study.

Frontiers in Psychiatry 2025 Zrinka Sosic-Vasic, Max Bergmann, Julia Kroener

The overarching goal of ACT is to increase psychological flexibility, which can be enhanced through mechanisms such as acceptance, valued-driven actions, or mindfulness. Several meta-analyses confirm the effectiveness of Acceptance and Commitment Therapy (ACT) in the treatment of clinical and subclinical populations, including patients diagnosed with depressive disorder and insomnia, largely...

DOI: 10.3389/fpsyt.2025.1673223 Full text Depression Act Inpatients Insomnia +1

Papers