Frontiers in Psychiatry
2026
Cancan Zhang, Jin Zhang, Lei Sun
Despite growing interest in mindfulness-based interventions (MBI) for Generalized Anxiety Disorder (GAD), robust evidence for their adjunctive use alongside first-line pharmacotherapy is scarce. This study aimed to evaluate the efficacy of MBI as adjunct to pharmacotherapy in adults with GAD, assessing multidimensional outcomes. In this randomized controlled trial, 106 adults diagnosed with...
Frontiers in Psychiatry
2026
Agnieszka Suchocka Capuano
Modern psychotherapy increasingly integrates multimodal and process-based approaches designed to respond to the complexity of contemporary clinical presentations. This paper introduces a three-pillar psychotherapeutic model combining (1) a revised cognitive behavioral foundation, (2) consciousness activation techniques derived from hypnosis, and (3) yoga-inspired postural and interoceptive...
Frontiers in Psychiatry
2026
Ying Sun, Shirong Bo, Yongsheng Li
Depression is a common complication after stroke. Although prior studies suggest that mindfulness-based stress reduction (MBSR) may alleviate depressive symptoms in post-stroke patients, the evidence remains inconclusive. This meta-analysis aimed to synthesize randomized controlled trials (RCTs) to evaluate the effects of MBSR on depressive symptoms after stroke. PubMed, Web of Science, Embase,...
Frontiers in Psychiatry
December 17, 2025
Veronika Savica, Liene Sīle, Māris Taube
1 citation
Dissociation is a complex and transdiagnostic phenomenon defined as a disruption of, or discontinuity in, the normal, subjective integration of one or more aspects of psychological functioning. Dissociation has been identified as one of the most frequently occurring adverse effects associated with the use of esketamine nasal sprays. Individuals with high trait dissociation may be at a higher...
Frontiers in Psychiatry
December 11, 2025
Sima Rafiei, Kristof Santa, Nicola Honey et al.
3 citations
Introduction: , a six-session VR mindfulness programme designed for young people, delivered in real-world school and community environments. Methods: Using an exploratory pre-post mixed-methods design, data were collected from 53 participants across schools, community organisations, and youth mental health services. Recruitment was facilitator-led and internal to each site. Quantitative data...
Frontiers in Psychiatry
December 10, 2025
Terence H. W. Ching, B. Stahnke, Sarah Shnayder et al.
3 citations
Introduction The subjective effects of psilocybin on obsessive-compulsive disorder (OCD) are under-explored. Therefore, we conducted a qualitative study of participant experiences from the first randomized placebo-controlled trial of single-dose psilocybin combined with unstructured and non-directive support for individuals with treatment-refractory OCD. Our research explored how participants...
Frontiers in Psychiatry
December 4, 2025
Adam Włodarczyk, Jakub Słupski, Joanna Szarmach et al.
Ketamine may be a viable treatment option for patients with treatment-resistant post-stroke depression. Further research is warranted to better understand the efficacy and safety of ketamine in this specific patient population.
Frontiers in Psychiatry
December 1, 2025
Aamer Aldbyani
3 citations
This article presents an expansive commentary on Rutledge's (2025) mixed-methods investigation into the role of faith practices in the psychological well-being of displaced Muslim women in northern Iraq. Rutledge's study makes an important contribution by demonstrating that religious devotion-particularly daily prayer, Qur'an recitation, and fasting-serves as a primary channel through which...
Frontiers in Psychiatry
September 22, 2025
Shannon Dames, Pamela Kryskow, Vivian W. L. Tsang et al.
3 citations
RTT-KaT offers a structured, scalable, evidence-informed, and culturally responsive model that bridges clinical safety with both Western and Indigenous knowledge systems. A longitudinal follow-up study is currently underway to evaluate long-term impact and guide future implementations.
Frontiers in Psychiatry
September 22, 2025
Charles Miller, Bárbara Lopes, Anna Mccurdy
In recent years, ketamine therapy has become increasingly entangled with psychedelic culture, leading to widespread misinterpretation of its therapeutic mechanism. This manuscript challenges the prevailing narrative that positions ketamine as a consciousness-expanding agent or psychotherapy enhancer, highlighting the discord between this view and ketamine's well-established neurobiological...
Frontiers in Psychiatry
September 11, 2025
Małgorzata Wierzbicka, Renata Kopczyk, Alexander L. Gerlach et al.
correction
[This corrects the article DOI: 10.3389/fpsyt.2025.1591864.].
Frontiers in Psychiatry
September 5, 2025
Nicholas J. Ahari, Gregory A. Fonzo
3,4-methelenedioxymethamphetamine (MDMA) can be effective in treating posttraumatic stress disorder (PTSD) in controlled trials, potentially secondary to MDMA’s effects on neural circuits implicated in fear and reward. Although anxiety, stress, and fear-based disorders involve maladaptation of the neural circuits processing fear, threat, and reward, no studies have tested MDMA’s therapeutic...
Frontiers in Psychiatry
September 2, 2025
Mina Kheirkhah, Nastasia McDonald, Julia Aepfelbacher et al.
1 citation
Introduction: This is the first randomized controlled trial to use both qualitative and quantitative methods to evaluate the effects of a combined sensory intervention that included mindfulness, music, and a light-occluding eye mask during antidepressant-dose ketamine treatment for depression. Methods: Forty-three participants with unipolar depressive disorder enrolled in the study; 22...
Frontiers in Psychiatry
August 19, 2025
Hebert W. Harris
This paper introduces Active Intersubjective Inference (AISI), a novel framework that integrates psychodynamic theory with predictive processing to explain self-identity construction and psychopathology. AISI posits that the self emerges from recursive inferences about how others perceive us (second-order self), interacting bidirectionally with interoceptive processes. We map psychodynamic...
Frontiers in Psychiatry
August 6, 2025
Grace Blest‐hopley, Giuseppe Pasculli, Simon Ruffell et al.
3 citations
Introduction Psilocybin, a serotonergic psychedelic, has shown therapeutic potential in treating mental health disorders by, amongst the many effects, promoting neuroplasticity and reorganising functional connectivity across cortical and subcortical networks involved in emotion and cognition. Veterans with traumatic brain injuries (TBI) often experience chronic neurological and psychological...
Frontiers in Psychiatry
August 4, 2025
Fernando Mora, J. Ramos-Quiroga, Enrique Baca-García et al.
5 citations
Introduction Depression is a highly prevalent disease that severely impacts the life of patients. Inadequate response to at least two antidepressants despite adequacy of treatment and adherence is known as treatment-resistant depression (TRD), which entails a higher social and economic burden than non-resistant major depression. The lack of consensus on the definition of TRD and other aspects...
Frontiers in Psychiatry
August 4, 2025
Wierzbicka Małgorzata, Renata Kopczyk, Alexander L. Gerlach et al.
1 citation
Depression prevalence is markedly elevated in oncological patients, particularly among head and neck cancer (HNC) cohorts, who face twice the prevalence of major depressive disorder (MDD) compared to other cancer populations. MDD in this context independently predicts poorer clinical outcomes and increased morbidity. HNC management often involves acute surgical interventions with disfiguring...
Frontiers in Psychiatry
July 18, 2025
Hui Kou, Wei Luo, Yiwei Wang et al.
2 citations
Background: The present study investigated the sustained effects of a 5-week EmotionCore mindfulness training program on emotion regulation, emotional intelligence (EI), trait mindfulness, depression, and anxiety among 120 undergraduates, while exploring the mediating mechanisms of training effect and heterogeneous effects across subgroups. Methods: Participants were randomly assigned to a...
Frontiers in Psychiatry
May 8, 2025
Yanping Lu, Longxin Dang, Yuan Tao
Cyberbullying victimization (CV) has been linked to numerous adverse psychological outcomes among adolescents. While previous research has established associations between CV and negative outcomes including depression, diminished self-esteem, and academic burnout, the potential protective mechanisms in these relationships remain underexplored. This longitudinal study investigated the mediating...
Frontiers in Psychiatry
April 15, 2025
Hao-Yan Li, Wen-jing Xu, Ya-Mei Wang et al.
Background Postoperative depression (POD) represents a serious complication in surgical patients, exacerbating morbidity and mortality rates while imposing a substantial economic burden on healthcare systems. Despite its widespread clinical use, the role of esketamine, an NMDA receptor antagonist with rapid antidepressant effects, remains understudied in perioperative settings. Therefore, we...
Frontiers in Psychiatry
April 1, 2025
Asli Ercan Dogan, Herdem Aslan Genç, S. Balaç et al.
Introduction Depression is a heterogeneous disorder with diverse clinical presentations and etiological underpinnings, necessitating the identification of distinct subtypes to enhance targeted interventions. Dissociative symptoms, commonly observed in major depressive disorder (MDD) and linked to early life trauma, may represent a unique clinical dimension associated with specific...
Frontiers in Psychiatry
March 6, 2025
T. Müller, Svenja Krug, Özlem Kayali et al.
Introduction The Attention Training Technique (ATT) is a psychotherapeutic intervention in Metacogntive Therapy (MCT) and aims at reducing maladaptive processes by strengthening attentional flexibility. ATT has demonstrated efficacy in treating depression on a clinical level. Here, we evaluated ATT at the neural level. We examined functional connectivity (FC) of the default mode network (DMN)....
Frontiers in Psychiatry
February 4, 2025
Xuejun Qi, Yonghui Shen, Xianwei Che et al.
Objective Although research on psychological interventions in generalized anxiety disorder (GAD) has provided evidence of their effectiveness regarding self-reported outcomes, few studies have examined their psychophysiological effects. Heart rate is emerging as a potential biomarker of efficacy in anxiety disorders. This study aimed to investigate the effects of a self-compassion intervention...
Frontiers in Psychiatry
January 30, 2025
Valerio Ricci, Alessandro Sarni, Giuseppe Maina
The relationship between substance use and the onset of psychosis has been a subject of clinical and academic debate for centuries. The potential for cannabis to trigger psychosis was first suggested by Grose in 1772, who documented issues related to cannabis use in India (1). Karl Jaspers later explored this connection in his Allgemeine Psychopathologie (1959), describing toxic intoxications...
Frontiers in Psychiatry
2025
Mary R. Shen, Dylan E Campbell, Anika Kopczynski et al.
10 citations
Opioid use disorder (OUD) continues to be a public health crisis in the United States, with mortality having doubled over the last twenty years, leading to significant economic cost, morbidity, and mortality. This has caused significant demand for novel therapeutics. Preliminary evidence demonstrates that ketamine may be helpful in treating OUD as well as serve as an adjunct during treatment of...