Preliminary evidence suggests that the combination of magnesium and ibogaine, an atypical psychedelic, may be a promising treatment for post-traumatic stress disorder (PTSD), opioid use disorder, and traumatic brain injury (TBI). The "mystical" experience elicited by ibogaine, which is characterized by feelings of awe, selflessness, and transcendence, is correlated with improvements in PTSD...
medRxiv Preprint ServerApril 19, 2026Cameron C. Glick, Saad Pirzada, Shaun K.l. Quah et al.
preprint
Background Scalable, low-burden behavioral interventions are needed to address rising subclinical mental health symptoms. However, few randomized controlled trials have evaluated ultra-brief, remotely delivered, meditation using multimodal outcome assessment under real-world conditions.
BackgroundIbogaine was recently found to result in significant functional improvements in treating the sequelae of traumatic brain injury (TBI) among Special Operations Forces veterans (SOVs). In the current study, we used multimodal neuroimaging to elucidate the neural correlates of ibogaine in 30 male SOVs who received ibogaine treatment.MethodsArterial spin labeling and blood oxygen...
Background: The COVID-19 pandemic significantly impacted mental health worldwide, particularly among college students. This study aimed to evaluate the effects of regular meditation practice on stress and well-being during the COVID-19 lockdown in college students from Delhi, India. Methods: Data were collected from April 22 to June 3, 2020. Participants included college students aged 18-26,...
Abstract Major Depressive Disorder (MDD) is typically characterized by altered linear functional connectivity (FC) across large-scale brain networks. Yet, it is unclear whether similar alterations are observed when nonlinear FC is examined. This study investigated how antidepressant treatment (i.e., psilocybin and escitalopram) modulates both linear FC and nonlinear FC in individuals with MDD....
Meditation training has been shown to enhance attention and improve emotion regulation. However, the brain processes associated with such training are poorly understood and a computational modeling framework is lacking. Modeling approaches that can realistically simulate neurophysiological data while conforming to basic anatomical and physiological constraints can provide a unique opportunity...
The capacity to focus one's attention for an extended period of time can be increased through training in contemplative practices. However, the cognitive processes engaged during meditation that support trait changes in cognition are not well characterized. We conducted a longitudinal wait-list controlled study of intensive meditation training. Retreat participants practiced focused attention...
Figure 1 (a) Model architecture for a single site (adapted from [1]).(b) Model estimated (in red) and experimental (in blue) spectra for a sample channel and subject.(c) Topographic map of the intrathalamic gain parameter before and after training.Reduction in intrathalamic gain has been linked to increase in alertness [2].Thus, the model not only fits experimental data but also provides a...