medRxiv
July 22, 2026
Kenneth Shinozuka, Clayton Olash, Tracy Han et al.
preprint
Preliminary evidence suggests that the combination of magnesium and ibogaine, an atypical psychedelic, may be a promising treatment for post-traumatic stress disorder (PTSD), opioid use disorder, and traumatic brain injury (TBI). The "mystical" experience elicited by ibogaine, which is characterized by feelings of awe, selflessness, and transcendence, is correlated with improvements in PTSD...
medRxiv Preprint Server
April 19, 2026
Cameron C. Glick, Saad Pirzada, Shaun K.l. Quah et al.
preprint
Background Scalable, low-burden behavioral interventions are needed to address rising subclinical mental health symptoms. However, few randomized controlled trials have evaluated ultra-brief, remotely delivered, meditation using multimodal outcome assessment under real-world conditions.
iScience
February 21, 2026
Andrew Geoly, John P. Coetzee, Derrick Matthew Buchanan et al.
= 22). Longitudinal analyses assessed cortical thickness, subcortical volume, and predicted brain age (pBA), estimated from T1 scans. pBA was significantly reduced at 1 month relative to baseline (-1.3 years). Cortical thickness analysis revealed post-treatment increases in 11 regions. Subcortical analyses revealed significant volumetric expansion in 8 regions. Magnesium-ibogaine therapy was...
Biological Psychiatry Cognitive Neuroscience and Neuroimaging
February 1, 2026
Malvika Sridhar, Azeezat Azeez, Andrew Geoly et al.
BackgroundIbogaine was recently found to result in significant functional improvements in treating the sequelae of traumatic brain injury (TBI) among Special Operations Forces veterans (SOVs). In the current study, we used multimodal neuroimaging to elucidate the neural correlates of ibogaine in 30 male SOVs who received ibogaine treatment.MethodsArterial spin labeling and blood oxygen...
bioRxiv (Cold Spring Harbor Laboratory)
March 10, 2025
Shaun K.l. Quah, Cameron C. Glick, Leor Roseman et al.
preprint
Abstract Major Depressive Disorder (MDD) is typically characterized by altered linear functional connectivity (FC) across large-scale brain networks. Yet, it is unclear whether similar alterations are observed when nonlinear FC is examined. This study investigated how antidepressant treatment (i.e., psilocybin and escitalopram) modulates both linear FC and nonlinear FC in individuals with MDD....
Neuroimage
July 1, 2015
Manish Saggar, Anthony P Zanesco, Brandon G King et al.
31 citations
Meditation training has been shown to enhance attention and improve emotion regulation. However, the brain processes associated with such training are poorly understood and a computational modeling framework is lacking. Modeling approaches that can realistically simulate neurophysiological data while conforming to basic anatomical and physiological constraints can provide a unique opportunity...
Frontiers in Human Neuroscience
2012
Manish Saggar, Brandon G King, Anthony P Zanesco et al.
136 citations
The capacity to focus one's attention for an extended period of time can be increased through training in contemplative practices. However, the cognitive processes engaged during meditation that support trait changes in cognition are not well characterized. We conducted a longitudinal wait-list controlled study of intensive meditation training. Retreat participants practiced focused attention...
BMC Neurosci
2010
Manish Saggar, Stephen R Aichele, Tonya L Jacobs et al.
50 citations
A computational approach to understanding the longitudinal changes in cortical activity associated with intensive meditation training