Frontiers in Psychiatry
July 13, 2026
Scott Shannon, Andrew T. Weil
Current psychiatric models, while clinically valuable, remain limited in their ability to account for the complexity, variability, and context dependence of mental disorders. Converging evidence from neuroscience, complexity science, and psychedelic research suggests that psychiatric symptoms may be better understood as stable patterns of organization within dynamic, multilevel systems rather...
Frontiers in Psychiatry
July 9, 2026
Alqassem Y. Hakami
Background Substance use disorders (SUDs) and treatment-resistant depression (TRD) remain a major global health challenge, marked by high relapse rates and limited long-term effectiveness of existing treatments. Ketamine, a glutamatergic modulator with rapid neuroplastic effects, has emerged as a novel intervention for TRD and is increasingly investigated as an adjunctive treatment for...
Frontiers in Psychiatry
July 9, 2026
Patrice A. Bellanti, Jordan Lewis, Brian Seifferth et al.
Introduction Intravenous (IV) ketamine and intranasal esketamine are NMDA receptor antagonists used for treatment-resistant depression (TRD). Both have demonstrated efficacy in controlled trials, but observational evidence from real-world community settings is limited. Methods We conducted a single-center retrospective cohort study of adults aged 18 to 65 receiving induction therapy for TRD...
Frontiers in Psychiatry
July 8, 2026
Lotem Zvi, Jonathan E. Handelzalts, Danny Horesh et al.
Background Worldwide, there are relatively few specialized inpatient units dedicated to women with histories of childhood sexual abuse (CSA) and comorbid psychiatric disorders. This pilot study examined dissociation and PTSD among women admitted to such a specialized integrative inpatient unit in Israel. We conduct an in-depth analysis of the role of dissociation in these women’s clinical...
Frontiers in Psychiatry
July 6, 2026
Qinglin Bao, Dezhi Yang, Zhiheng Dong et al.
Self-referential processing (SRP), the mental activity of linking experiences and stimuli to the self, is fundamental to shaping identity, regulating affect, and navigating complex social environments. Disruptions in SRP are increasingly recognized as a transdiagnostic hallmark across psychiatric disorders, including schizophrenia spectrum disorders, major depressive disorder, and anxiety...
Frontiers in Psychiatry
July 3, 2026
Jingqiang Xie, Chunying Pu, Mingyue Sun
Treatment-resistant depression (TRD) remains a major clinical challenge. Intranasal esketamine, used adjunctively with an oral antidepressant, has been evaluated in randomized trials, but uncertainty persists regarding the magnitude and consistency of benefit, durability, and key harms. This systematic review and meta-analysis included randomized controlled trials comparing intranasal...
Frontiers in Psychiatry
July 2, 2026
Ranran Zhao, Yuan-Yuan Li, Feifei Meng et al.
Background Humanistic care competence and psychological resilience are essential for improving nursing quality, particularly in high-stress specialties such as obstetrics. However, effective interventions that simultaneously enhance both interpersonal and intrapersonal capacities among nurses remain limited. Methods A total of 87 obstetric nurses from a tertiary hospital in Hebei Province,...
Frontiers in Psychiatry
July 1, 2026
Chun-Hung Chang, Yu-Der Hsia, W Liu et al.
Introduction Treatment-resistant major depressive disorder with high-risk suicidal ideation is a psychiatric emergency that requires rapid and effective intervention. Although intranasal esketamine and intermittent theta-burst stimulation (iTBS) are time-efficient therapeutic options, clinical reports describing their combined use in an accelerated inpatient schedule are limited, particularly...
Frontiers in Psychiatry
June 29, 2026
Minglei Sun, H. Wu, Ming Deng et al.
Respiratory modulation has emerged as a measurable psychomotor phenotype and a promising non-invasive approach for the regulation of affective disturbances. In this study, a mechanismdriven real-time respiratory modulation framework is proposed to investigate its rapid effects on affective states and underlying neurophysiological dynamics in the context of computational psychiatry. A total of...
Frontiers in Psychiatry
June 24, 2026
Kathryn Fletcher, Nadine Ezard, Krista J. Siefried et al.
Background Methamphetamine use disorder (MAUD) is associated with substantial psychiatric and physical morbidity, and current treatment options remain limited. Ketamine-assisted psychotherapy (KAP) has shown promise in substance use disorders, but little is known about how individuals experience and interpret this intervention, particularly in MAUD. Qualitative investigation may provide insight...
Frontiers in Psychiatry
June 11, 2026
Mohammed Salah Alfahal, Mohamed Hassan, Maryam Alowais
Background Dissociative amnesia with dissociative fugue is a rare dissociative disorder characterized by abrupt loss of autobiographical memory and disruption of personal identity, most often emerging in the context of severe psychological stress. Although dissociative phenomena are increasingly recognized in individuals with suicidal behavior, the development of fugue states in the immediate...
Frontiers in Psychiatry
June 10, 2026
Wesley H. Fleming
A growing body of psychological and neuroscientific research suggests that moral injury (MI) involves maladaptive self-referential processing, including disruptions in moral identity, rigid negative self-appraisals, and impaired meaning-making following exposure to potentially morally injurious events (PMIEs). Building on Mindfulness-to-Meaning Theory (MMT), this paper proposes...
Frontiers in Psychiatry
June 10, 2026
Justyna Śniadach, Sylwia Szymkowiak, Przemysław Osip et al.
Background: Cannabis use has increased across Europe over the last decade, accompanied by growing availability of high-potency THC products and rising psychiatric presentations. Despite these trends, European countries differ substantially in monitoring systems, clinical preparedness and public health responses. These disparities are especially visible between Western Europe, which has more...
Frontiers in Psychiatry
May 15, 2026
Kaevon Brasfield, Eugene Pahk, Conrado Sevilla
Nitrous oxide is a dissociative hallucinogen that is increasingly used recreationally, in part due to its widespread availability. Its use is known to cause subacute combined degeneration via inactivation of vitamin B12; it may also result in acute delirium and chronic progressive encephalopathy. Though current practice guidelines call for treatment of neurological sequelae of nitrous oxide use...
Frontiers in Psychiatry
May 13, 2026
Feliciano Yu, Joe Tafur, Francisco Moreno et al.
2 citations
Importance: The Oregon Psilocybin Services (OPS) program is the first statewide, regulated framework for legal psilocybin in the U.S. Analyzing inaugural-year utilization and safety is essential for informing policy and equity monitoring. Methods: We conducted a descriptive analysis of statewide aggregate data from the OPS Public Dashboard (January 1-December 31, 2025). Outcomes included...
Frontiers in Psychiatry
April 15, 2026
Samuel G. Myers, Stian Solem
Background Detached Mindfulness (DM) is a central, transdiagnostic technique within Metacognitive Therapy (MCT). It involves increasing meta-awareness of intrusions while decentring from and disengaging with them, and is used to reduce the Cognitive Attentional Syndrome and dysfunctional metacognitive beliefs—key components of the metacognitive model of psychological disorders. Although DM is...
Frontiers in Psychiatry
April 13, 2026
Craig F. Ferris
For the past half-century, psychiatric drug development has largely focused on tweaking neurotransmitter receptors and chemical pathways. Yet despite billions of dollars invested and major advances in neuroscience, truly innovative treatments for mental illness remain scarce. Disorders like depression, schizophrenia, and post-traumatic stress disorder (PTSD) continue to be managed with drugs...
Frontiers in Psychiatry
April 7, 2026
Ravi Philip Rajkumar
Post-traumatic stress disorder (PTSD) is a chronic mental illness that occurs following exposure to traumatic stressors such as combat, disasters, or assault. It is characterized by a triad of reexperiencing of the trauma, avoidance of triggers for such recollections, and increased vigilance towards threats (1). In 1992, Judith Herman described a variant of PTSD that occurred in persons who had...
Frontiers in Psychiatry
April 1, 2026
Jonathan Stellmacher, Christopher Schmidt, Helena Aicher et al.
Research on the therapeutic effects of psychedelics in psychiatry, commonly referred to as Psychedelic-Assisted Therapy (PAT), has expanded substantially in recent years. The context-dependent nature of psychedelics has sparked discussion about the importance of the psychotherapeutic environment in achieving beneficial outcomes. This study explores the contribution of psychotherapeutic factors...
Frontiers in Psychiatry
March 31, 2026
O. Fedyk, B. Croissant, C. Schulz et al.
Background Mindfulness-based interventions show promise for trauma-related conditions, yet controlled trials examining their efficacy for dissociative symptoms remain scarce. This feasibility study evaluated whether Mindfulness-Based Training (MBT), when added to cognitive-behavioral therapy (CBT), reduces dissociative symptoms more effectively than CBT combined with guided physical exercise....
Frontiers in Psychiatry
March 6, 2026
Lucas Ferrer Nappe
Neurobiological advances-from Global Neuronal Workspace (GNW) and Integrated Information Theory (IIT) to predictive processing-have transformed how we model conscious access, integration, and inference. These frameworks primarily explain capacities and mechanisms (how information becomes globally available, is integrated, or is prediction-driven), not what is experienced in a situation nor what...
Frontiers in Psychiatry
March 4, 2026
Robert Queissner, F. Fellendorf, E. Z. Reininghaus
Background Bipolar depression remains a leading cause of morbidity, functional impairment, and suicide risk in bipolar disorder. Conventional pharmacotherapies often provide delayed or incomplete relief and may increase the risk of treatment-emergent affective switching. Recent evidence highlights the therapeutic potential of NMDA receptor antagonists, particularly ketamine and its S-enantiomer...
Frontiers in Psychiatry
February 25, 2026
Rosemarij J. B. van Veen, Jan Dirk Blom, Emma H. C. van Rooijen et al.
1 citation
Introduction: Sexual hallucinations have lifetime prevalence rates of 0.4% in the general population and up to 44% in schizophrenia spectrum disorders. For borderline personality disorder (BPD) these rates are unknown. We therefore studied prevalence rates of sexual hallucinations and delusions in this group, as well as their phenomenological characteristics and their connection with childhood...
Frontiers in Psychiatry
February 16, 2026
Jian Sun
Current paradigms for understanding Narcissistic Personality Disorder (NPD)-including psychoanalytic, cognitive-behavioral, and neuroscientific approaches-offer valuable insights but remain fragmented. They largely fail to explain the deep motivational structure of narcissism, particularly the co-existence of grandiose and vulnerable subtypes and the disorder's profound resistance to treatment....
Frontiers in Psychiatry
January 22, 2026
Jae Sevelius, Rachel Lynn Golden, B. Stott et al.
1 citation
Introduction Transgender and gender-expansive people experience high rates of depression, anxiety, and trauma-related distress, yet few evidence-based interventions are tailored to their needs. Kindred is a novel, group-based ketamine-assisted psychotherapy (KAP) program that integrates cognitive processing therapy (CPT) to address identity-based trauma. Methods This mixed-methods pilot study...