Treatment-resistant depression (TRD) remains a major clinical challenge. Intranasal esketamine, used adjunctively with an oral antidepressant, has been evaluated in randomized trials, but uncertainty persists regarding the magnitude and consistency of benefit, durability, and key harms. This systematic review and meta-analysis included randomized controlled trials comparing intranasal...
Background and purpose: Occupational mental health is critical in the high-emotional-labor field of social work. Grounded in the Conservation of Resources (COR) theory, this study investigates the underlying mechanisms linking occupational stress to subclinical psychopathology. Specifically, we propose and test an integrative moderated serial mediation model to explore how Psychotic-like...
Background Humanistic care competence and psychological resilience are essential for improving nursing quality, particularly in high-stress specialties such as obstetrics. However, effective interventions that simultaneously enhance both interpersonal and intrapersonal capacities among nurses remain limited. Methods A total of 87 obstetric nurses from a tertiary hospital in Hebei Province,...
Introduction Treatment-resistant major depressive disorder with high-risk suicidal ideation is a psychiatric emergency that requires rapid and effective intervention. Although intranasal esketamine and intermittent theta-burst stimulation (iTBS) are time-efficient therapeutic options, clinical reports describing their combined use in an accelerated inpatient schedule are limited, particularly...
Respiratory modulation has emerged as a measurable psychomotor phenotype and a promising non-invasive approach for the regulation of affective disturbances. In this study, a mechanismdriven real-time respiratory modulation framework is proposed to investigate its rapid effects on affective states and underlying neurophysiological dynamics in the context of computational psychiatry. A total of...
Background Methamphetamine use disorder (MAUD) is associated with substantial psychiatric and physical morbidity, and current treatment options remain limited. Ketamine-assisted psychotherapy (KAP) has shown promise in substance use disorders, but little is known about how individuals experience and interpret this intervention, particularly in MAUD. Qualitative investigation may provide insight...
Background Dissociative amnesia with dissociative fugue is a rare dissociative disorder characterized by abrupt loss of autobiographical memory and disruption of personal identity, most often emerging in the context of severe psychological stress. Although dissociative phenomena are increasingly recognized in individuals with suicidal behavior, the development of fugue states in the immediate...
Frontiers in PsychiatryJune 10, 2026Justyna Śniadach, Sylwia Szymkowiak, Przemysław Osip et al.
Background: Cannabis use has increased across Europe over the last decade, accompanied by growing availability of high-potency THC products and rising psychiatric presentations. Despite these trends, European countries differ substantially in monitoring systems, clinical preparedness and public health responses. These disparities are especially visible between Western Europe, which has more...
A growing body of psychological and neuroscientific research suggests that moral injury (MI) involves maladaptive self-referential processing, including disruptions in moral identity, rigid negative self-appraisals, and impaired meaning-making following exposure to potentially morally injurious events (PMIEs). Building on Mindfulness-to-Meaning Theory (MMT), this paper proposes...
Nitrous oxide is a dissociative hallucinogen that is increasingly used recreationally, in part due to its widespread availability. Its use is known to cause subacute combined degeneration via inactivation of vitamin B12; it may also result in acute delirium and chronic progressive encephalopathy. Though current practice guidelines call for treatment of neurological sequelae of nitrous oxide use...
Importance: The Oregon Psilocybin Services (OPS) program is the first statewide, regulated framework for legal psilocybin in the U.S. Analyzing inaugural-year utilization and safety is essential for informing policy and equity monitoring. Methods: We conducted a descriptive analysis of statewide aggregate data from the OPS Public Dashboard (January 1-December 31, 2025). Outcomes included...
Background: Sexual desire disorders are increasingly conceptualized within biopsychosocial and regulatory models that emphasize inhibitory processes-such as evaluative self-monitoring, maladaptive expectancy, avoidance learning, relational insecurity, and stress dysregulation-rather than primary absence of excitation. Mindfulness-based interventions and clinical hypnotherapy both target core...
Background and hypothesis Cannabis use initiation during adolescence has increased globally, raising concerns about neurodevelopmental consequences during this critical period when the brain undergoes extensive remodeling in cannabinoid receptor-rich regions. Study design This systematic review examines neurodevelopmental consequences of adolescent cannabis use, focusing on structural brain...
Background Detached Mindfulness (DM) is a central, transdiagnostic technique within Metacognitive Therapy (MCT). It involves increasing meta-awareness of intrusions while decentring from and disengaging with them, and is used to reduce the Cognitive Attentional Syndrome and dysfunctional metacognitive beliefs—key components of the metacognitive model of psychological disorders. Although DM is...
For the past half-century, psychiatric drug development has largely focused on tweaking neurotransmitter receptors and chemical pathways. Yet despite billions of dollars invested and major advances in neuroscience, truly innovative treatments for mental illness remain scarce. Disorders like depression, schizophrenia, and post-traumatic stress disorder (PTSD) continue to be managed with drugs...
Post-traumatic stress disorder (PTSD) is a chronic mental illness that occurs following exposure to traumatic stressors such as combat, disasters, or assault. It is characterized by a triad of reexperiencing of the trauma, avoidance of triggers for such recollections, and increased vigilance towards threats (1). In 1992, Judith Herman described a variant of PTSD that occurred in persons who had...
Research on the therapeutic effects of psychedelics in psychiatry, commonly referred to as Psychedelic-Assisted Therapy (PAT), has expanded substantially in recent years. The context-dependent nature of psychedelics has sparked discussion about the importance of the psychotherapeutic environment in achieving beneficial outcomes. This study explores the contribution of psychotherapeutic factors...
Background Mindfulness-based interventions show promise for trauma-related conditions, yet controlled trials examining their efficacy for dissociative symptoms remain scarce. This feasibility study evaluated whether Mindfulness-Based Training (MBT), when added to cognitive-behavioral therapy (CBT), reduces dissociative symptoms more effectively than CBT combined with guided physical exercise....
Neurobiological advances-from Global Neuronal Workspace (GNW) and Integrated Information Theory (IIT) to predictive processing-have transformed how we model conscious access, integration, and inference. These frameworks primarily explain capacities and mechanisms (how information becomes globally available, is integrated, or is prediction-driven), not what is experienced in a situation nor what...
Background Bipolar depression remains a leading cause of morbidity, functional impairment, and suicide risk in bipolar disorder. Conventional pharmacotherapies often provide delayed or incomplete relief and may increase the risk of treatment-emergent affective switching. Recent evidence highlights the therapeutic potential of NMDA receptor antagonists, particularly ketamine and its S-enantiomer...
Introduction: Sexual hallucinations have lifetime prevalence rates of 0.4% in the general population and up to 44% in schizophrenia spectrum disorders. For borderline personality disorder (BPD) these rates are unknown. We therefore studied prevalence rates of sexual hallucinations and delusions in this group, as well as their phenomenological characteristics and their connection with childhood...
BackgroundA range of singing interventions exist for mental health contexts, but few have incorporated group-based body, breathwork and vocal improvisation. The Feldenkrais method has potential to support singing interventions by raising attention to body and breath. This study aimed to describe practice and evaluate experiences and outcomes of a Feldenkrais and group vocal improvisation...
Current paradigms for understanding Narcissistic Personality Disorder (NPD)-including psychoanalytic, cognitive-behavioral, and neuroscientific approaches-offer valuable insights but remain fragmented. They largely fail to explain the deep motivational structure of narcissism, particularly the co-existence of grandiose and vulnerable subtypes and the disorder's profound resistance to treatment....
Introduction Transgender and gender-expansive people experience high rates of depression, anxiety, and trauma-related distress, yet few evidence-based interventions are tailored to their needs. Kindred is a novel, group-based ketamine-assisted psychotherapy (KAP) program that integrates cognitive processing therapy (CPT) to address identity-based trauma. Methods This mixed-methods pilot study...
The postpartum period is notorious for rapid and profound changes for birthing individuals and their families. Significant shifts to hormonal and physical health, routines and family roles, and the salience of personal and community risk factors all contribute to potential psychiatric and psychological distress for parents, sometimes diagnosed as a postpartum mood or anxiety disorder (PMAD)....