Journal of Psychedelic Studies
July 18, 2024
Alex P. Hood, Chris E. Corlett, Cameron T Alldredge et al.
1 citation
AbstractBackground and AimsPost-Traumatic Stress Disorder (PTSD) is a debilitating condition that affects a sizable proportion of U.S. civilians, military personnel, and veterans. 3,4-Methylenedioxymethamphetamine-Assisted Therapy (MDMA-AT) is a novel treatment approach for PTSD that has both stirred media enthusiasm and drawn criticism. This critical review analyzes individual randomized,...
Journal of Psychedelic Studies
July 17, 2024
Liam Engel, Sascha Thal, Stephen Bright et al.
4 citations
Abstract Background and aims Online communities provide insights into psychedelic consumption, assisting in identification of trends, informing both harm reduction provisions and clinical research. This study extracts forum data on psychedelic substances, dosages, and administration routes, categorising and analysing self-reported consumption to inform care services and guide clinical work with...
Journal of Psychedelic Studies
July 15, 2024
Christopher Quasti, Dominic Sisti
5 citations
Abstract Psychedelic-assisted therapy (PAT) is currently undergoing a resurgence of clinical interest for several mental health ailments. We propose that philosophers can play a significant role in PAT in both the preparation and integration phases of PAT. Philosophers can aid in the former phase by offering philosophical preparatory insights and in the latter phase by providing the conceptual...
Journal of Psychedelic Studies
July 12, 2024
Kristoffer Andreas Aamodt Andersen, Bjørn Holmøy, Lowan H. Stewart
1 citation
Abstract Background Previous international clinical trials have indicated that mystical experiences resulting from the consumption of classic psychedelic drugs, such as psilocybin, may represent a subjective psychological mechanism of action associated with therapeutic effects for various mental disorders. The revised 30-item Mystical Experience Questionnaire is one of several psychometric...
Journal of Psychedelic Studies
July 11, 2024
Alyssa B. Oliva, Mitch Earleywine, Fiona Low et al.
AbstractBackground and AimsResearch on psychedelic-assisted therapy (PAT), a promising treatment option for major depression, has not revealed if potential clients show preferences about the demographic characteristics of providers comparable to those common in other forms of psychotherapy. Previous work suggests that honoring comparable client preferences can enhance therapeutic outcomes. This...
Journal of Psychedelic Studies
June 21, 2024
Bryan Mccarthy, Hunt Priest
6 citations
As the wider culture is experiencing what some call a “psychedelic renaissance,” various Christian voices are beginning to comment on this cultural moment in the press and social media. Some are curious, even open minded, about the developments; others are expressing concern about what they see as the inauthenticity and danger of psychedelics as a spiritual practice. In the academic literature,...
Journal of Psychedelic Studies
June 21, 2024
Caroline Griffin, Alec Knight
3 citations
AbstractBackground and aimsPsychedelics show promise for treatment of mental health conditions (MHCs). But there is relatively little research on indigenous psychedelics conducted in the Global South (GS). Much research is carried out in the Global North, where there are different cultural perceptions of mental health and psychedelics. Therefore, this paper appraises research on psychedelics...
Journal of Psychedelic Studies
June 5, 2024
Meghan DellaCrosse, Albert Garcia‐romeu, Alan K. Davis
4 citations
Despite growing interest in psychedelic-assisted therapy (PAT) research, there remains a lack of consensus about key issues relevant to difficulties in predicting acute drug effects, and the role of therapeutic support in clinical trials. In the absence of a clear theoretical model to conceptualize multifaceted components in PAT research, dialogue across contexts (e.g., popular media, peer...
Journal of Psychedelic Studies
May 31, 2024
Evan E. Ozmat, Alicia K. Mcdonough, Guy M. Ladouceur et al.
4 citations
Abstract Background and aims Ibogaine, an alkaloid extracted from the root of the Tabernanthe Iboga shrub, holds promise in treating addictive disorders. Individuals receiving ibogaine treatment report decreased withdrawal symptoms, cravings, and addiction severity. These changes are often attributed to ibogaine's psychedelic properties: subjectively meaningful, dream-like experiences. Research...
Journal of Psychedelic Studies
May 30, 2024
Jacob S. Aday, Kevin F. Boehnke, Moss Herberholz et al.
3 citations
Psychedelic-assisted psychotherapy (PAP) is currently being studied as a possible treatment option for multiple disorders. Despite promising safety and efficacy findings, the high costs of the current PAP model makes it questionable if the treatment will be scalable. Non-hallucinogenic psychedelic analogs have been developed as a potential cost-effective alternative, but it is unclear what...
Journal of Psychedelic Studies
May 27, 2024
Lisa L. Gezon
7 citations
This qualitative ethnographic study of a psychedelic integration group in the Southeastern United States contributes to an understanding of the role of supportive communities in processing psychedelic experiences. This article proposes the concept of ‘social efficacy’ to capture the importance of social relationships to the efficacy of psychedelics. Social efficacy refers to a source of...
Journal of Psychedelic Studies
May 27, 2024
Tehseen Noorani, R. Liebert
2 citations
With a surge in critiques levelled against the evidence generated by randomised controlled trials in the study of psychedelic-assisted therapy (PAT), and the legalization of PAT in select jurisdictions such as Australia, and Oregon and Colorado in the United States, we consider what form the real-world evidence of its effects could take. Specifically, we propose to complement individual-level...
Journal of Psychedelic Studies
May 27, 2024
Joanna Pashdag
1 citation
AbstractOver the past decade, numerous open-label studies and early clinical trials have shown that psychedelics hold promise for the fast and possibly lasting relief of a wide range of conditions ranging from major depressive disorder, end-of-life anxiety, and obsessive-compulsive disorder to smoking, alcohol use, and eating disorders. Among the questions still to be resolved in this endeavor...
Journal of Psychedelic Studies
May 10, 2024
Maria Bălăeţ
5 citations
This commentary addresses the potential for a nocebo effect arising from the public discourse on psychedelics, especially considering the increasing interest and engagement with these substances. The resurgence of psychedelics in the public and scientific arenas has led to a proliferation of discussions, both positive and cautionary, about their use. However, an imbalance in this discourse,...
Journal of Psychedelic Studies
May 10, 2024
Jarrett Robert Rose
3 citations
Revival, resurgence, renaissance-call it what you will, we are bearing witness to a second age of psychedelia in the West.It is well understood that the fruits borne of today's great scientific, therapeutic, and cultural advancements owe much to the seeds planted by the giants of the past.Yet when that past is discussed, the conversation is often dominated by the influence of only a select few...
Journal of Psychedelic Studies
May 6, 2024
Mark Cornfield, S. Mcbride, Joseph T. la Torre et al.
6 citations
This study contributes to the understanding of the efficacy, safety, and experience of ketamine-assisted therapy. The paper documents how individuals describe the effects of a protocolized and personalized use of ketamine (‘the relational dose’) in the context of group couples therapy based on Imago Relationship Therapy (IRT). Little is known about simultaneously administering ketamine to both...
Journal of Psychedelic Studies
April 5, 2024
Brian Pilecki, Jason B. Luoma, Kati M. Lear
9 citations
Abstract Psychological flexibility has been proposed as a core process of change when psychedelics are used for therapeutic purposes, but to date empirical outcomes have only documented changes on the Acceptance and Action Questionnaire (AAQ-II), a very general measure of psychological flexibility. This pilot study measured outcomes from psilocybin administered in a retreat setting across a...
Journal of Psychedelic Studies
April 5, 2024
Dusty R. Miller, Jordan Taylor Jacobs, Alan Rockefeller et al.
7 citations
Abstract Psilocybe zapotecorum is a strongly blue-bruising psilocybin mushroom used by indigenous groups in southeastern Mexico and beyond. While this species has a rich history of ceremonial use, research into its chemistry and genetics has been limited. Herein, we report on mushroom morphology, cultivation parameters, chemical profile, and the full genome sequence of P. zapotecorum . First,...
Journal of Psychedelic Studies
April 2, 2024
M. Nordin, Jón Ingi Hlynsson, Jakob Håkansson Eklund et al.
17 citations
Abstract Background and aims Interest in psychedelic research has grown significantly in recent years and the naturally derived substance psilocybin, in combination with therapy, has shown promising results as a treatment for a range of psychiatric conditions. However, the negative effects and risks of psilocybin-assisted treatment are not well-established. The purpose of this study was to...
Journal of Psychedelic Studies
April 2, 2024
Stefanie Desrochers
5 citations
Abstract Background and Aims Despite increasing public acceptance of the LGBTQ+ community and psychedelic medicines, published accounts of queer psychedelia are limited. Specifically, the queer nature of psychedelics and the parallels between narratives of being queer and of psychedelic experiences, are lacking. This report brings queer experiences of psychedelia out of the metaphorical closet...
Journal of Psychedelic Studies
April 2, 2024
Sonia M. Brodie, Chelsea Stunden, Jay A. Olson et al.
AbstractBackground and aimsFirst responders such as firefighters and police officers often experience traumatic events as part of their work. As a result, they are more likely to have mental health issues such as post-traumatic stress disorder, depression, and anxiety compared to the general population. Psychedelic-assisted therapy has emerged as a promising avenue to alleviate these issues,...
Journal of Psychedelic Studies
March 29, 2024
Arghavan Nepton, Hesam Farahani, Monnica T. Williams et al.
2 citations
Abstract Background Hypotheses surrounding the etiology of depressive disorders encompass a wide range of biological changes that can occur in a depressed individual, from gene variations to epigenetic modifications and not only serotonergic mechanisms. Once again, the therapy response of the patient to antidepressants is connected to modifications in the epigenetic regulation of genes within...
Journal of Psychedelic Studies
March 21, 2024
Denis Fradkin
3 citations
Abstract As reliable facilitators of characteristically unique altered states of consciousness that are notoriously difficult to comprehend, psychedelics naturally attract a multidisciplinary scope for their research, with direct relevance to neuroscience, pharmacology, psychology, as well as philosophy of mind, metaphysics, and epistemology — disciplines united by the common inquiry into the...
Journal of Psychedelic Studies
March 5, 2024
Aaron D. Cherniak, Mario Mikulincer, Joel Gruneau Brulin et al.
7 citations
Abstract Background and aims Emerging research indicates that psychedelics may have therapeutic potential by fostering meaningful experiences that act as “inflection points” in people's narratives of personal development. However, psychedelic research has largely failed to address pertinent developmental considerations. We investigated whether attachment-related variables were associated with...
Journal of Psychedelic Studies
March 5, 2024
Mitch Earleywine, Alyssa B. Oliva, Joseph A. de Leo et al.
6 citations
Though several treatments effectively address the pervasive impact of trauma, they do not achieve complete symptom resolution for all clients, inspiring the search for alternatives. Internal Family Systems (IFS) therapy has grown popular, especially in informal psychedelic-assisted treatments (PAT). Compared to stereotypes of empirically validated, exposure-based treatments, IFS has novel...