Experiences of psychedelic drug use among people with psychotic symptoms and disorders: Personal growth and mystical experiences

Abstract

Individuals with a history of psychotic experiences and disorders such as schizophrenia, and mood disorders with psychotic features tend to be excluded from psychedelic-assisted therapy research and treatment programs, despite minimal research demonstrating heightened risk of adverse effects for this group. Participants (n = 100) were asked to complete an online, retrospective survey that asked about psychotic experiences and/or diagnoses and one memorable psychedelic experience, along with mental health histories, dose used, set and setting, and other relevant variables including whether they mixed their psychedelic with other substances. Respondents also completed pertinent psychometric questionnaires and answered questions regarding the impact of their psychedelic experience on their well-being, mental health, relationships, spiritual beliefs, and aspects of their life. Thematic inductive analysis was used to identify recurring themes. Most respondents (n = 88) stated that their psychedelic experience resulted in some degree of personal growth. Many also described mystical-type experiences, increased levels of contemplation and spirituality, improved insight, symptomatic improvements, and feelings of love and appreciation following the experience. Most described overall positive experiences, however, 11% (n = 11) described overall negative experiences, which included symptom exacerbation, dysphoria, and terror, and a slightly larger portion described mixed-type experiences.