Metabolic Burden and Response to Repeated Intranasal Esketamine in Treatment-Resistant Depression: A Longitudinal Multidomain Biomarker Study
Research Square September 7, 2026 preprint DOI: 10.21203/rs.3.rs-10923483/v1 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Longitudinal biomarker study |
|---|---|
| Population | Patients with treatment-resistant depression |
| Intervention | Intranasal esketamine |
| Topics | Depression Esketamine |
| Key findings | Higher metabolic burden was associated with poorer response to repeated intranasal esketamine, indicating that metabolic factors may influence treatment outcomes in treatment-resistant depression. |
Abstract
Metabolic Burden and Response to Repeated Intranasal Esketamine in Treatment-Resistant Depression: A Longitudinal Multidomain Biomarker Study