BMJ Open
July 5, 2024
Michael Schlegelmilch, Amy C. Plint, Nicholas Barrowman et al.
2 citations
Suicidal ideation (SI) is a common and severe cause of morbidity in adolescents. Patients frequently present to the emergency department (ED) for care, yet there is no acute therapeutic intervention for SI. A single dose of intravenous ketamine has demonstrated efficacy in rapidly reducing SI in adults; however, ketamine has not been studied in paediatrics. We aim to determine the feasibility...
BMJ Open
May 1, 2024
Ben Beaglehole, Richard Porter, Katie Douglas et al.
5 citations
Although short-term benefits follow parenteral ketamine for treatment-resistant major depressive disorder (TR-MDD), there are challenges that prevent routine use of ketamine by clinicians. These include acute dissociative effects of parenteral ketamine, high relapse rates following ketamine dosing and the uncertain role of psychotherapy. This randomised controlled trial (RCT) seeks to establish...
BMJ Open
April 1, 2024
Shampa Maji, Debadatta Mohapatra, Monalisa Jena et al.
Background Therapeutic latency, lack of efficacy and adverse drug reactions are the major concerns in current antidepressant therapies. To overcome these treatment hurdles, add-on therapy to conventional antidepressant medications may lead to better therapeutic outcomes. The present randomised controlled trial has been planned to evaluate the efficacy and safety of add-on dextromethorphan to...
BMJ Open
March 1, 2024
Charlie Song-Smith, Edward Jacobs, James Rucker et al.
9 citations
Objective To capture UK medical students’ self-reported knowledge and harm assessment of psychedelics and to explore the factors associated with support for changing the legal status of psychedelics to facilitate further clinical research. Design Cross-sectional, anonymous online survey of UK medical students using a non-random sampling method. Setting UK medical schools recognised by the...
BMJ Open
November 23, 2023
Adam P. Wagner, Julieta Galante, Géraldine Dufour et al.
7 citations
Cost-effectiveness of providing university students with a mindfulness-based intervention to reduce psychological distress: economic evaluation of a pragmatic randomised controlled trial.
BMJ Open
September 25, 2023
Cen Chen, Qingfeng Wei, Jiajia Zhu et al.
7 citations
Introduction Depressive symptoms have surfaced as the principal mental health concern among patients with breast cancer, with surgical interventions potentially exacerbating these symptoms and adversely influencing clinical outcomes. This study protocol is designed to investigate the efficacy of low-dose esketamine administered perioperatively on depressive symptoms in patients with breast...
BMJ Open
May 1, 2023
Alan K. Davis, Adam W. Levin, Paul Nagib et al.
19 citations
Introduction Psilocybin-assisted therapy has shown significant promise in treating the cluster of mood and anxiety symptoms that comprise post-traumatic stress disorder (PTSD) but has yet to be tested specifically in this condition. Furthermore, current pharmacological and psychotherapeutic treatments for PTSD are difficult to tolerate and limited in efficacy, especially in the US Military...
BMJ Open
November 26, 2022
Nick Glozier, Ben Colagiuri, Dean J Wright
3 citations
Objectives To compare attitudes of mental health (MH) professionals towards trials of methylenedioxymethamphetamine-assisted psychotherapy (MDMA-AP), with a neutrally labelled pharmacotherapy trial.Design A randomised controlled vignette study design, with experimenters blinded to group condition.Setting Participants were recruited online via professional societies.Participants Psychiatrists,...
BMJ Open
October 1, 2022
Mathias Ebbesen Jensen, Dea Siggaard Stenbæk, Tobias Søgaard Juul et al.
21 citations
Introduction Alcohol use disorder is a difficult-to-treat psychiatric disorder and a major burden on public health. Existing treatment efficacy is moderate, and relapse rates are high. Preliminary findings suggest that psilocybin, a psychedelic compound, can safely and reliably occasion highly meaningful experiences that may spur a positive change in drinking behaviour when administered in a...
BMJ Open
August 25, 2022
Peter J Bayley, R Jay Schulz-Heik, Julia S Tang et al.
Test whether Sudarshan Kriya Yoga (SKY) was non-inferior to cognitive processing therapy (CPT) for treating symptoms of post-traumatic stress disorder (PTSD) among veterans via a parallel randomised controlled non-inferiority trial. Outpatient Veterans Affairs healthcare centre. 85 veterans (75 men, 61% white, mean age 56.9) with symptoms of PTSD participated between October 2015 and March...
BMJ Open
December 1, 2021
James Rucker, Hassan Jafari, Tim Mantingh et al.
23 citations
Introduction Psilocybin-assisted therapy may be a new treatment for major depressive disorder (MDD), with encouraging data from pilot trials. In this trial (short name: PsiDeR) we aimed to test the feasibility of a parallel-group, randomised, placebo-controlled design. The primary outcomes in this trial are measures of feasibility: recruitment rates, dropout rates and the variance of the...
BMJ Open
November 12, 2021
Meditation involving people with cancer, medical staff and witnesses: a pilot study exploring improvement in wellness and connectedness.
BMJ Open
May 28, 2021
Florian Junne, Alexander Bäuerle, Martin Teufel et al.
Introduction The SARS-CoV-2 (COVID-19) pandemic poses immense challenges for national and international healthcare systems. Especially in times of social isolation and governmental restrictions, mental health should not be neglected. Innovative approaches are required to support psychologically burdened people. The e-mental health intervention ‘CoPE It’ has been developed to offer manualised...
BMJ Open
November 12, 2020
Marloes J Huijbers, Carolien Wentink, Anne Speckens et al.
Objectives This study aimed to explore predictors and outcomes associated with different trajectories of discontinuing antidepressant medication (ADM), in recurrently depressed individuals after participation in mindfulness-based cognitive therapy (MBCT). Facilitators and barriers of discontinuation were explored qualitatively.Design Mixed-methods study combining quantitative and qualitative...
BMJ Open
November 5, 2020
Tatjana Ewais, Jake Begun, Maura Kenny et al.
Objectives Mindfulness-based cognitive therapy (MBCT) is effective in treating psychosocial comorbidities in inflammatory bowel disease (IBD); however, there have been no qualitative studies of MBCT experiences among youth with IBD. We aimed to examine the experiences of youth with IBD and depression who completed an adapted MBCT group programme, and the impact of common psychotherapy and group...
BMJ Open
November 28, 2019
Moving 2 Mindful (M2M) study protocol: testing a mindfulness group plus ecological momentary intervention to decrease stress and anxiety in adolescents from high-conflict homes with a mixed-method longitudinal design.
BMJ Open
July 4, 2019
Charlotte Todd, Roxanne Cooksey, Helen Davies et al.
21 citations
Mixed-methods evaluation comparing the impact of two different mindfulness approaches on stress, anxiety and depression in school teachers.
BMJ Open
April 3, 2019
Danielle C Mathersul, Julia S Tang, R Jay Schulz-Heik et al.
Post-traumatic stress disorder (PTSD) is a debilitating, highly prevalent condition. Current clinical practice guidelines recommend trauma-focused psychotherapy (eg, cognitive processing therapy; CPT) as the first-line treatment for PTSD. However, while these treatments show clinically meaningful symptom improvement, the majority of those who begin treatment retain a diagnosis of PTSD...
BMJ Open
September 24, 2018
Julie Lynch, Lucia Prihodova, Pádraic J Dunne et al.
Rates of burnout and stress in healthcare practitioners are steadily increasing. Emergency department (ED) staff are particularly susceptible to such poor outcomes. Mantra meditation (MM) may contribute to increased well-being. The primary aim of this study was to obtain indepth qualitative feedback on ED staff's experience of a MM programme. A secondary objective was to harness staff's...
BMJ Open
2018
Martin Lamothe, P. McDuff, Yves D Pastore et al.
Objectives To assess the feasibility and acceptability of a mindfulness-based stress reduction (MBSR)-based intervention and determine if the intervention is associated with a significant signal on empathy and emotional competencies. Design Two pre–post proof-of-concept studies. Setting Participants were recruited at the University of Montreal’s Psychology Department (Study 1) and the CHU...
BMJ Open
September 1, 2017
Elena Argento, Steffanie A. Strathdee, Kenneth W. Tupper et al.
60 citations
Objective This study aimed to longitudinally investigate whether ever having used a psychedelic drug can have a protective effect on incidence of suicidality among marginalised women. Design Longitudinal community-based cohort study. Setting Data were drawn from a prospective, community-based cohort of marginalised women in Metro Vancouver, Canada. Participants 766 women completed the baseline...
BMJ Open
November 1, 2016
Julieta Galante, Géraldine Dufour, Alice Benton et al.
46 citations
INTRODUCTION: Levels of stress in UK university students are high, with an increase in the proportion of students seeking help in recent years. Academic pressure is reported as a major trigger. Mindfulness training has been shown to reduce stress and is popular among students, but its effectiveness in this context needs to be ascertained. In this pragmatic randomised controlled trial, we...
BMJ Open
May 1, 2015
L. Leung, Han Han, Mary I Martin et al.
Introduction Chronic non-cancer pain (CNCP) affects up to 50% of the world's population. It impacts negatively on quality of life; entailing high costs on our medical systems, and translates to economic burden due to work loss. Aetiology of CNCP is complex and multifactorial, embracing the somatosensory, cognitive and affective domains. Opioid analgesia and other invasive interventions are...
BMJ Open
November 1, 2013
Adele Krusche, Eva Cyhlarova, J Mark G Williams
Objectives Face-to-face mindfulness interventions have been shown to significantly decrease perceived stress, anxiety and depression and research is beginning to show similar benefits for such courses delivered via the internet. We investigated the feasibility and effectiveness of an online mindfulness course for perceived stress, anxiety and depression. Design A follow-up investigation of an...
BMJ Open
2012
Adele Krusche, Eva Cyhlarova, Scott King et al.
120 citations
OBJECTIVES: Stress has been shown to have a number of negative effects on health over time. Mindfulness interventions have been shown to decrease perceived stress but access to interventions is limited. Therefore, the effectiveness of an online mindfulness course for perceived stress was investigated. DESIGN: A preliminary evaluation of an online mindfulness course. PARTICIPANTS: This sample...